DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Ret

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	286	Identity:	91/286 - (31%)
Similarity:	147/286 - (51%)	Gaps:	24/286 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly  1055 RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKL-------DVAVKTCRMTLPDEQKRKFLQEGRI 1112
            :||...:.:.|...:|.|.||.|.|.  .:|::       .||||..:......:....|.|.::
  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKG--FATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQL 825

  Fly  1113 LKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN----------SNG---LTTRQQMG 1164
            |::..|||::||:|.|...:..::::|....|||.:|||.:          ::|   :..:..:.
  Fly   826 LQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLT 890

  Fly  1165 MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWT 1227
            .......||.||.....:||||||||.|:......||||||::|:  |::..:.....::||||.
  Fly   891 FAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWM 955

  Fly  1228 APEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRL 1292
            |||:|....|||..||||:|:|.||:.:.|.:||.|:........:.|||||..|::..|.:|.:
  Fly   956 APESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSI 1020

  Fly  1293 MLQCWAADAESRPHFDEIYNVVDALI 1318
            :..|||.:...||.|..:.:..:.|:
  Fly  1021 VRTCWADEPNGRPSFKFLASEFEKLL 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	88/269 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	87/269 (32%)
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	89/279 (32%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	88/272 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910