DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and MAP3K11

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens

Alignment Length:	297	Identity:	95/297 - (31%)
Similarity:	139/297 - (46%)	Gaps:	59/297 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1059 SNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQ----KRKFLQEGRILKQYDHP 1119
            |..::.|.|.||.|.||.||:...:...  ||||..|.. |||.    .....||.|:.....||
Human   113 SFQELRLEEVIGIGGFGKVYRGSWRGEL--VAVKAARQD-PDEDISVTAESVRQEARLFAMLAHP 174

  Fly  1120 NIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQ-----QMGMCRDAAAGMRYLESK 1179
            ||:.|..:|:::..:.:|||...||.|       |..|..|:     .:......|.||.||
Human   175 NIIALKAVCLEEPNLCLVMEYAAGGPL-------SRALAGRRVPPHVLVNWAVQIARGMHYL--- 229

  Fly  1180 NC------IHRDLAARNCLV-------DLEH-SVKISDFGMSRE--EEEYIVSDGMKQIPVKWTA 1228
            :|      |||||.:.|.|:       |:|| ::||:|||::||  :...:.:.|    ...|.|
Human   230 HCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAG----TYAWMA 290

  Fly  1229 PEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGY-------RMPTPKSTP 1286
            ||.:....::...||||:|:|:||:.: |:.||.|:      :.:...|       .:|.|.:.|
Human   291 PEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGI------DCLAVAYGVAVNKLTLPIPSTCP 348

  Fly  1287 EEMYRLMLQCWAADAESRPHFDEIYNVVDAL---ILR 1320
            |...:||..|||.|...||.|..|...::||   :||
Human   349 EPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLR 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	89/279 (32%)
		PTKc_Fes_like	1067..1315	CDD:270637	89/279 (32%)
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992
		STKc_MLK3	113..379	CDD:271049	91/289 (31%)
		STYKc	117..376	CDD:214568	90/282 (32%)
		Leucine-zipper 1	403..424
		Leucine-zipper 2	438..459
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810