Protein Alignment FER and MAP3K10

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_011525283.1
• Gene: MAP3K10 / 4294
• HGNCID: 6849
• Length: 962
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 122/499 - (24%)
• Similarity: 178/499 - (35%)
• Gaps: 176/499 - (35%)

  Fly   864 VEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASD 928
            :|:..|:.|.|  ....|||  ||..:|                    .|.:...|||......|
Human     1 MEEEEGAVAKE--WGTTPAG--PVWTAV--------------------FDYEAAGDEELTLRRGD 41

  Fly   929 DVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQI 993
            .|..:...|        ::|       .:|.|:.|.||...|       |.|
Human    42 RVQVLSQDC--------AVS-------GDEGWWTGQLPSGRV-------GVF------------- 71

  Fly   994 VLSVCWNGHKHFIVQTTGEGNFRFEGPPFASI-----QELIMHQYHSELPVTVKSGAILRRPVCR 1053
                              ..|:...|.|.|..     ||:..|:...|
Human    72 ------------------PSNYVAPGAPAAPAGLQLPQEIPFHELQLE----------------- 101

  Fly  1054 ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQK------RKFLQEGRI 1112
                         |.||.|.||.||:|..:..  :||||..|:   |.:|      .:..||.|:
Human   102 -------------EIIGVGGFGKVYRALWRGE--EVAVKAARL---DPEKDPAVTAEQVCQEARL 148

  Fly  1113 LKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQ-----QMGMCRDAAAG 1172
            .....||||:.|.|.|:....:.:|||...||:|       |..|..|:     .:......|.|
Human   149 FGALQHPNIIALRGACLNPPHLCLVMEYARGGAL-------SRVLAGRRVPPHVLVNWAVQVARG 206

  Fly  1173 MRYLESK---NCIHRDLAARNCLVDLE----HS-----VKISDFGMSRE--EEEYIVSDGMKQIP 1223
            |.||.:.   ..|||||.:.|.|: ||    |:     :||:|||::||  :...:.:.|    .
Human   207 MNYLHNDAPVPIIHRDLKSINILI-LEAIENHNLADTVLKITDFGLAREWHKTTKMSAAG----T 266

  Fly  1224 VKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGY-------RMPT 1281
            ..|.|||.:....::...||||:|:|:||:.: |:.||      |..:.:...|       .:|.
Human   267 YAWMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPY------REIDALAVAYGVAMNKLTLPI 324

  Fly  1282 PKSTPEEMYRLM--------LQCWAADAESRPHFDEIYNVVDAL 1317
            |.:.||...||:        .:||..|...||.|..|...::.:
Human   325 PSTCPEPFARLLEGEPGPRDEECWDPDPHGRPDFGSILKRLEVI 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	16/90 (18%)
		TyrKc	1063..1311	CDD:197581	87/287 (30%)
		PTKc_Fes_like	1067..1315	CDD:270637	88/287 (31%)
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992	19/128 (15%)
		TyrKc	98..365	CDD:197581	89/320 (28%)
		PKc_like	103..368	CDD:304357	87/288 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810