DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and MET

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_011514525.1	Gene:	MET / 4233	HGNCID:	7029	Length:	1409	Species:	Homo sapiens

Alignment Length:	1189	Identity:	265/1189 - (22%)
Similarity:	433/1189 - (36%)	Gaps:	376/1189 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 CALNEVGCE---ELPSGCDDDLTLEQNFIENGYNNEQQRSNST-------------SSPGLGIMN 439
            |::|. |..   |:|..|  .||            |:::..||             |.||..:..
Human   301 CSINS-GLHSYMEMPLEC--ILT------------EKRKKRSTKKEVFNILQAAYVSKPGAQLAR 350

  Fly   440 ELMRRGGVLT--LLRGRGRHFKRKSTPQPATPMTRSR---------QGRFNKLQPRSQSLGSLSV 493
            ::   |..|.  :|.|    ...:|.|..|.||.||.         ...|||:..::    ::..
Human   351 QI---GASLNDDILFG----VFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKN----NVRC 404

  Fly   494 IRDGNGPSPARYEPITNHR-LRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVV 557
            ::...||:   :|...|.. ||.::......:|..|..|     |.|:|..   |.:|:..|
Human   405 LQHFYGPN---HEHCFNRTLLRNSSGCEARRDEYRTEFT-----TALQRVD---LFMGQFSE--- 455

  Fly   558 LASPAPLTQLTAAVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNS 622
                         ||..:.:..|..||.: ....||     :|..:|       :.::::.|..
Human   456 -------------VLLTSISTFIKGDLTI-ANLGTS-----EGRFMQ-------VVVSRSGPST- 493

  Fly   623 IDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEENH----IQTRKLAKDP-DSQTKRSSSSS 682
                    ..:|.:||..     ..|.:|....:..:|.    |..:|:.|.| :....|...|.
Human   494 --------PHVNFLLDSH-----PVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSC 545

  Fly   683 SECRSS---------KDTSHSKKRSLS--FSQK----SISNIFSNLKEFSKSPLVRMGKNHIL-- 730
            |:|.|:         .|.....:..||  ::|:    :|..:|.|     .:||  .|...:.
Human   546 SQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPN-----SAPL--EGGTRLTIC 603

  Fly   731 --------NEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSN----------NNNNNKNTSSNSNHS 777
                    |.:.|.|:|:....:.|    |....|.|:.|          |.:.|.:...::.|.
Human   604 GWDFGFRRNNKFDLKKTRVLLGNES----CTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHG 664

  Fly   778 ASQ-ST------IITS--------------TIT-----------TTITTTTTTTPSKENSRLKFK 810
            .:| ||      :|||              |:|           .:|...|.|..|..||.|:..
Human   665 TTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECY 729

  Fly   811 VPKIQKKSKAIRNTFRSK----LLNFQLK----RSKPCKQCTKRRRIHPSKS------------- 854
            .|     ::.|...|..|    |.|.:..    |..|...     .|||:||
Human   730 TP-----AQTISTEFAVKLKIDLANRETSIFSYREDPIVY-----EIHPTKSFISGGSTITGVGK 784

  Fly   855 -------------VFDFAKEFEVEQPAGSAADEQFCNCPPAGQ---------------------- 884
                         |.:..:.|.|.....|.::...|..|...|
Human   785 NLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKY 849

  Fly   885 -----------KPVKPSVQISGHKDHPFESSSGELDE---------------------------- 910
                       ||.:..|.||...::..|....::|.
Human   850 FDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCT 914

  Fly   911 --------NSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPR 967
                    ||:.:|:..:....:....|:...|..: ...:|..:|:|| ..|....:|..:..|
Human   915 VPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNF-TGLIAGVVSIST-ALLLLLGFFLWLKKR 977

  Fly   968 EEVVRLLNNDGDFLVR-----------------------ETIRNE---------ESQIVLSVCWN 1000
            :::..|    |..|||                       |.:.||         |.|...| ..|
Human   978 KQIKDL----GSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNS-SQN 1037

  Fly  1001 GHKHFI---------VQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERW 1056
            |....:         :.|:|:.:  ...|...:...:.:...:.||...|:.  ::..|
Human  1038 GSCRQVQYPLTDMSPILTSGDSD--ISSPLLQNTVHIDLSALNPELVQAVQH--VVIGP------ 1092

  Fly  1057 ELSNDDVVLLERIGRGNFGDVYKAKL---KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDH 1118
              |:..|...|.||||:||.||...|   ...|:..|||:........:..:||.||.|:|.:.|
Human  1093 --SSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSH 1155

  Fly  1119 PNIVKLIGICVQKQ--PIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNC 1181
            ||::.|:|||::.:  | ::|:..:..|.|..::|..::..|.:..:|.....|.||:||.||..
Human  1156 PNVLSLLGICLRSEGSP-LVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF 1219

  Fly  1182 IHRDLAARNCLVDLEHSVKISDFGMSR---EEEEYIVSD--GMKQIPVKWTAPEALNFGKYTSLC 1241
            :|||||||||::|.:.:||::|||::|   ::|.|.|.:  |.| :||||.|.|:|...|:|:..
Human  1220 VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAK-LPVKWMALESLQTQKFTTKS 1283

  Fly  1242 DVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPH 1306
            ||||:|:|:||:.::|..||..:........:..|.|:..|:..|:.:|.:||:||...||.||.
Human  1284 DVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPS 1348

  Fly  1307 FDEIYNVVDALILRLDNSH 1325
            |.|:.:.:.|:.......|
Human  1349 FSELVSRISAIFSTFIGEH 1367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	21/126 (17%)
		TyrKc	1063..1311	CDD:197581	98/257 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/257 (38%)
MET	XP_011514525.1	Sema_MET	44..535	CDD:200539	63/313 (20%)
		PSI	538..580	CDD:214655	9/41 (22%)
		IPT_plexin_repeat1	582..675	CDD:238585	21/103 (20%)
		IPT_plexin_repeat2	676..759	CDD:238584	18/87 (21%)
		IPT_plexin_repeat3	761..856	CDD:238586	13/99 (13%)
		IPT	857..953	CDD:214657	12/96 (13%)
		Pkinase_Tyr	1097..1356	CDD:285015	98/260 (38%)
		PTKc_Met_Ron	1101..1362	CDD:270649	98/262 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810