DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and MATK

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_002369.2	Gene:	MATK / 4145	HGNCID:	6906	Length:	508	Species:	Homo sapiens

Alignment Length:	393	Identity:	140/393 - (35%)
Similarity:	200/393 - (50%)	Gaps:	58/393 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   948 SLSTNRPLYEEEWFHGVLPREEVVRLLN--NDGDFLVRETIRNEESQIVLSVCW----------- 999
            :||.:..|....||||.:..:|.|:.|.  .||.|||||:.|: ....||.|.:
Human   111 ALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARH-PGDYVLCVSFGRDVIHYRVLH 174

  Fly  1000 -NGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAI---LRRP---------- 1050
             :||     .|..|..|      |.::.:::.| |..:      .|||   |.||
Human   175 RDGH-----LTIDEAVF------FCNLMDMVEH-YSKD------KGAICTKLVRPKRKHGTKSAE 221

  Fly  1051 --VCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRIL 1113
              :.|..|.|:...:.|..:||.|.||.|.:.:....|  ||||..:.   |...:.||.|..::
Human   222 EELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQK--VAVKNIKC---DVTAQAFLDETAVM 281

  Fly  1114 KQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGL-TTRQQMGMCRDAAAGMRYLE 1177
            .:..|.|:|:|:|: :..|.:.||||.|..|:|:.:||.....| .|.|.:......|.||.|||
Human   282 TKMQHENLVRLLGV-ILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLE 345

  Fly  1178 SKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCD 1242
            ||..:||||||||.||..:...|:||||:::.|.:.:.|   .::||||||||||..||:||..|
Human   346 SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDS---SRLPVKWTAPEALKHGKFTSKSD 407

  Fly  1243 VWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF 1307
            |||:|:|:||:||.|..||..|:.....|.::.||||..|:..|..::.||..||.|:...||.|
Human   408 VWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472

  Fly  1308 DEI 1310
            .::
Human   473 RKL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/99 (27%)
		TyrKc	1063..1311	CDD:197581	102/249 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/245 (41%)
MATK	NP_002369.2	SH3_CHK	51..109	CDD:212745
		SH3 domain	55..106
		SH2_csk_like	119..216	CDD:198190	32/115 (28%)
		SH2 domain	123..213		32/108 (30%)
		PTKc_Chk	229..482	CDD:270666	104/256 (41%)
		catalytic domain	236..479		102/249 (41%)
		STYKc	236..479	CDD:214568	102/249 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810