DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and LYN

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:XP_011515831.1 Gene:LYN / 4067 HGNCID:6735 Length:682 Species:Homo sapiens


Alignment Length:641 Identity:186/641 - (29%)
Similarity:274/641 - (42%) Gaps:161/641 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   812 PKIQKKSKAIRNTFRSKLLNFQLK-RSKPCKQCTKRRRI---------HPSKSVFDFAKEFEVEQ 866
            |.:|:|:....:|.||..|:.|:. .||||...|...:.         .||      ....::..
Human    52 PSLQEKAGPGCSTPRSCRLSRQVSVPSKPCATATPNTQTLGRDQTVTSPPS------GLNMQIRA 110

  Fly   867 PAGS------AADEQFCN------C---------------PPA---------------------- 882
            |..|      ..|.||.:      |               |||                      
Human   111 PGSSWDLSAEPRDSQFLSRRAGPRCRSLPGRGASGPDALQPPARGKRGGRATPGPAPAAPRRASS 175

  Fly   883 --GQ----------KPVKPSVQISGHKDHP----FESSSGELDEN----SDRDIDNDEEEE---- 923
              ||          :||.|....|.|:..|    |...  .:.|:    ..|....|.||:    
Human   176 VPGQQPPHTQVLLGRPVAPPTLNSSHRGAPPPRNFHRE--RVPESQLLPGQRFQTKDPEEQGDIV 238

  Fly   924 ------DSASDDVLSMK---------DH--CYCVPSLAAS----------ISLSTNRPLYEEEWF 961
                  |....|.||.|         :|  .:...||...          ..|:|   |..||||
Human   239 VALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNT---LETEEWF 300

  Fly   962 HGVLPREEVVRLL----NNDGDFLVR--ETIRNEESQIVLS---VCWNGHKHFIVQTTGEGNFRF 1017
            ...:.|::..|.|    |:.|.||:|  ||::...|..|..   |..:..||:.:::...|.: :
Human   301 FKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGY-Y 364

  Fly  1018 EGP--PFASIQELIMHQYHSELPVTVKSGAILRR------------PVCRERWELSNDDVVLLER 1068
            ..|  .|..|.::|.| |..:      :..:.||            |..::.||:..:.:.|::|
Human   365 ISPRITFPCISDMIKH-YQKQ------ADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKR 422

  Fly  1069 IGRGNFGDVYKAKL-KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQ 1132
            :|.|.||:|:.... .|||  |||||.:......|  .||:|..::|...|..:|:|..:..:::
Human   423 LGAGQFGEVWMGYYNNSTK--VAVKTLKPGTMSVQ--AFLEEANLMKTLQHDKLVRLYAVVTREE 483

  Fly  1133 PIMIVMELVLGGSLLTYLRKNSNG-LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLE 1196
            ||.|:.|.:..||||.:|:.:..| :...:.:......|.||.|:|.||.|||||.|.|.||...
Human   484 PIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSES 548

  Fly  1197 HSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDT 1259
            ...||:|||::|  |:.||...:|.| .|:|||||||:|||.:|...||||:|||::||.:.|..
Human   549 LMCKIADFGLARVIEDNEYTAREGAK-FPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKI 612

  Fly  1260 PYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVD 1315
            ||.|.||:.....:..|||||..::.|:|:|.:|..||...||.||.||.:.:|:|
Human   613 PYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD 668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 27/96 (28%)
TyrKc 1063..1311 CDD:197581 104/251 (41%)
PTKc_Fes_like 1067..1315 CDD:270637 104/251 (41%)
LYNXP_011515831.1 SH3_Lyn 237..292 CDD:212937 8/54 (15%)
SH2_Src_Lyn 295..395 CDD:198227 28/107 (26%)
PTKc_Lyn 409..680 CDD:270657 108/265 (41%)
Pkinase_Tyr 417..667 CDD:285015 104/254 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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