DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and LTK

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_016877670.1	Gene:	LTK / 4058	HGNCID:	6721	Length:	885	Species:	Homo sapiens

Alignment Length:	356	Identity:	116/356 - (32%)
Similarity:	175/356 - (49%)	Gaps:	59/356 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   990 ESQIVLSV---CWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRP- 1050
            :|:::||:   .|.|                       :||:.:.....||. .:::.||...|
Human   463 DSRLLLSMKQKKWQG-----------------------LQEMRLPSPELELS-KLRTSAIRTAPN 503

  Fly  1051 --VCR------ERW-------ELSNDDVVLLERIGRGNFGDVYKAKL-----KSTKLDVAVKTCR 1095
              .|:      :.|       |:|..:|.||..:|.|.||:||:..:     .|:.|.||:||..
Human   504 PYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLP 568

  Fly  1096 MTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN------S 1154
            .....:.:..||.|..|:.::.|.|||:.:|:.::..|.:|::||:.||.:.::||.:      .
Human   569 ELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQP 633

  Fly  1155 NGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDL---EHSVKISDFGMSRE--EEEYI 1214
            :.|..|..:.:.:|.|.|..|||..:.||||:||||||:..   ....||.||||:|:  ...|.
Human   634 SPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYY 698

  Fly  1215 VSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRM 1279
            .......:||||..|||...|.:||..|.||:|:|:|||||.|..||.|.||....:.:..|.||
Human   699 RRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRM 763

  Fly  1280 PTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            ..|:..|..:||:|.|||..:.|.||.|..|
Human   764 DPPRGCPGPVYRIMTQCWQHEPELRPSFASI 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	9/51 (18%)
		TyrKc	1063..1311	CDD:197581	100/264 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/260 (37%)
LTK	XP_016877670.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910