Protein Alignment FER and syk

DIOPT Version :10

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_005155595.1
• Gene: syk / 405769
• ZFINID: ZDB-GENE-040702-3
• Length: 608
• Species: Danio rerio
• Alignment Length: 522
• Identity: 157/522 - (30%)
• Similarity: 242/522 - (46%)
• Gaps: 123/522 - (23%)

  Fly   881 PAGQKPVKPSVQISGHKDHPFESSSGELDENSDRD-IDNDEEEEDSASDD-VLSMKDHCYCVPSL 943
            |.|.:|          |..|||    :|.|...|. ::.....:.||.|. ::|.:      |.|
Zfish   105 PRGTEP----------KVGPFE----DLKEQLIRQYVEQTWNLKGSALDQAIISQR------PQL 149

  Fly   944 AASISLSTNRPLYEEEWFHGVLPREE-VVRLLNN---DGDFLVRE---TIRNEESQIVLSVCWNG 1001
            ...|:.:.:..:   .||||.:.||: .:||||.   :|.||:|:   :.|||...:.| :..|.
Zfish   150 EKLIATTAHEKM---PWFHGKIDREDSELRLLNTSRVNGKFLIRQRENSGRNESYALCL-LHNNQ 210

  Fly  1002 HKHFIVQTTGEGNFRF-EGPPFASIQELIMH-------------------QYHSELPVTVKSGAI 1046
            ..|:.:.....|.... :|..|.::.:|:.|                   .:|||...|   |.|
Zfish   211 VMHYRIDKDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTETCPRPSHHSERGAT---GGI 272

  Fly  1047 LRR-----------------------------------------PVCRERWE------------- 1057
            :.|                                         |:..:.:|
Zfish   273 ISRLKSYSFPKPGQKKGSAENPYKITPNGKDDYSKQGNFLDSAMPMDTQVYESPYADPDELRSTK 337

  Fly  1058 LSNDDVVLLE-RIGRGNFGDVYKA--KLKSTKLDVAVKTCRMTLPDEQ---KRKFLQEGRILKQY 1116
            ::..|:.|.: .:|.||||.|.:.  ::|.|:..||||..:.  .|:.   |.:.|:|..:::|.
Zfish   338 VNRSDLTLEDGELGSGNFGTVLRGVYQMKKTQKVVAVKILKN--DDDNAAVKDEMLREANVMQQL 400

  Fly  1117 DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNC 1181
            |:|.||::|||| :.:.:|:||||...|.|..:|:||.: :|.:....:....:.||:|||..|.
Zfish   401 DNPYIVRMIGIC-EAENLMLVMELAELGPLHKFLQKNKH-ITVKNLTELVHQVSMGMKYLEEHNF 463

  Fly  1182 IHRDLAARNCLVDLEHSVKISDFGMSR---EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDV 1243
            :||||||||.|:..:|..||||||:|:   |:|.|..:.|..:.|:||.|||.:|:.|::|..||
Zfish   464 VHRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKAKGHGKWPLKWYAPECMNYLKFSSKSDV 528

  Fly  1244 WSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFD 1308
            ||:|:||||.||.|..||.||..:...:.|:.|.||..|...|.|||.||.:||....:.||.|.
Zfish   529 WSFGVLMWEAFSYGQKPYKGMKGNEVIQMIENGQRMSAPPDCPPEMYDLMKKCWTYKPDERPGFS 593

  Fly  1309 EI 1310
            .:
Zfish   594 VV 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	28/112 (25%)
		PTKc_Fes_like	1067..1315	CDD:270637	104/253 (41%)
syk	XP_005155595.1	SH2_N-SH2_Zap70_Syk_like	8..111	CDD:198191	3/15 (20%)
		SH2_C-SH2_Syk_like	159..260	CDD:198264	25/104 (24%)
		PTKc_Syk	348..604	CDD:133247	104/252 (41%)