DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and pik3r2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_997987.2	Gene:	pik3r2 / 404211	ZFINID:	ZDB-GENE-040309-1	Length:	724	Species:	Danio rerio

Alignment Length:	436	Identity:	88/436 - (20%)
Similarity:	156/436 - (35%)	Gaps:	133/436 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   748 SGSDCPTNSSSSSSNNNNNNKNTSSNSN------HSASQSTI-ITSTITTTITTTTTTTPSKENS 805
            ||.||.|...:|:|:|...:.:...:.:      |:.|::.| ....:...|......|..:...
Zfish   139 SGLDCRTLYRTSASDNQRPSLSELQDLDVGQWDIHALSEAVIRYLQDLPAPIIPPCVYTDLQAAV 203

  Fly   806 RLKFKVPKIQ----------KKSKAIRNTFRSKLLNFQLKR-SKPCKQCTKRRRIHPSKSVFDFA 859
            :|:..||.::          |....::|..   .|::.|:. .|.|:..        .::..|..
Zfish   204 QLESDVPSVRRRELLQQVLDKPEVPLQNLL---TLHYLLQHLDKVCQSA--------EQNGLDIY 257

  Fly   860 KEFEVEQP-------AGSAADEQFCNCPPAG-----------QKPVKPSVQISGHKDHPFESSSG 906
            ...::..|       :||..||.|   |.|.           |:|..|::.....|
Zfish   258 TLGQIFGPLLFRGPVSGSEEDEAF---PAAAVERLLLERIWEQEPTPPALPPKPPK--------- 310

  Fly   907 ELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVV 971
                                             ..::|:|::..::..|.|.||:.|.:.||||.
Zfish   311 ---------------------------------AKAMASSVTNGSDSLLSEAEWYWGDISREEVN 342

  Fly   972 RLLNN--DGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGP-PFASIQELIMH-- 1031
            ..:.:  ||.||||:.......:..|::...|:...|......|.:.|..| .|.|:.|||.|
Zfish   343 EKMRDTPDGTFLVRDASSKVHGEYTLTLRKGGNNKLIKIFHRGGKYGFSEPLTFLSVVELINHYR 407

  Fly  1032 -----QYHSEL------PVT-------VKSGAI----LRRPVCRERW-ELSNDDVVLLERIGRGN 1073
                 ||:::|      ||:       ||..:|    .:..|..|:: |.|.:..||.|...|.:
Zfish   408 HESLAQYNAKLDSHLLFPVSKYQQDQVVKEDSIEAVGEQLKVYHEQYQEKSREYDVLYEEYTRSS 472

  Fly  1074 FGDVYKAKLKSTKLDVAVKTCRM---------TLPDEQKRKFLQEG 1110
                .:.::|.|.::...:|.::         .|..:...||.:||
Zfish   473 ----QELQMKRTAIEAFNETIKIFEEQCETQERLSRDSIEKFRREG 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/101 (30%)
		TyrKc	1063..1311	CDD:197581	12/57 (21%)
		PTKc_Fes_like	1067..1315	CDD:270637	10/53 (19%)
pik3r2	NP_997987.2	SH3_PI3K_p85beta	6..79	CDD:212842
		RhoGAP	113..298	CDD:295372	31/172 (18%)
		SH2_nSH2_p85_like	326..433	CDD:198195	32/106 (30%)
		PI3K_P85_iSH2	437..596	CDD:293063	17/82 (21%)
		iSH2_PIK3R2	438..598	CDD:214019	17/81 (21%)
		SH2_cSH2_p85_like	616..720	CDD:198184
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910