DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and LIMK2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001026971.1	Gene:	LIMK2 / 3985	HGNCID:	6614	Length:	686	Species:	Homo sapiens

Alignment Length:	276	Identity:	75/276 - (27%)
Similarity:	131/276 - (47%)	Gaps:	47/276 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1062 DVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIG 1126
            |::..|.:|:|.||...|...|:|...:.:|.. :...:|.::.||.|.::::..||||::|.||
Human   309 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKEL-IRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 372

  Fly  1127 ICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNC 1191
            :..:.:.:.::.|.:.||:|..:|| :.:....:|::...:..|:||.||.|...|||||.:.||
Human   373 VLYKDKKLNLLTEYIEGGTLKDFLR-SMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNC 436

  Fly  1192 LVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVK-------------------------WTAPEA 1231
            |:.|:.:|.::|||:||     ::.:..|:.|::                         |.|||.
Human   437 LIKLDKTVVVADFGLSR-----LIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEM 496

  Fly  1232 LNFGKYTSLCDVWSYGILMWEIFSK--GDTPYSGMTNSRARERIDTGYRMP------TPKSTPEE 1288
            ||...|....|::|:||::.||..:  .|......|       :|.|..:.      .|...|..
Human   497 LNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRT-------LDFGLNVKLFWEKFVPTDCPPA 554

  Fly  1289 MYRLMLQCWAADAESR 1304
            .:.|...|...:.|||
Human   555 FFPLAAICCRLEPESR 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	74/275 (27%)
		PTKc_Fes_like	1067..1315	CDD:270637	74/271 (27%)
LIMK2	NP_001026971.1	LIM	<15..44	CDD:295319
		LIM2_LIMK2	46..104	CDD:188849
		PDZ	131..215	CDD:278991
		PKc_like	316..570	CDD:328722	71/267 (27%)
		PP1_inhibitor	564..686	CDD:283108	3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910