DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and LIMK1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_002305.1	Gene:	LIMK1 / 3984	HGNCID:	6613	Length:	647	Species:	Homo sapiens

Alignment Length:	295	Identity:	83/295 - (28%)
Similarity:	145/295 - (49%)	Gaps:	30/295 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1049 RPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRIL 1113
            |.|||........|::..|.:|:|.||...|...:.|. :|.|....:...:|.:|.||:|.:::
Human   325 RVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETG-EVMVMKELIRFDEETQRTFLKEVKVM 388

  Fly  1114 KQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLES 1178
            :..:|||::|.||:..:.:.:..:.|.:.||:|...::...:.....|::...:|.|:||.||.|
Human   389 RCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHS 453

  Fly  1179 KNCIHRDLAARNCLVDLEHSVKISDFGMSR-EEEEYIVSDGMKQI--PVK-----------WTAP 1229
            .|.|||||.:.||||....:|.::|||::| ..:|....:|::.:  |.:           |.||
Human   454 MNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAP 518

  Fly  1230 EALNFGKYTSLCDVWSYGILMWEIFSK--GDTPYSGMTNSRARERIDTGYRMP------TPKSTP 1286
            |.:|...|....||:|:||::.||..:  .|..|...|       :|.|..:.      .|.:.|
Human   519 EMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRT-------MDFGLNVRGFLDRYCPPNCP 576

  Fly  1287 EEMYRLMLQCWAADAESRPHFDEIYNVVDALILRL 1321
            ...:.:.::|...|.|.||.|.::.:.::.|.:.|
Human   577 PSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHL 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	76/269 (28%)
		PTKc_Fes_like	1067..1315	CDD:270637	76/269 (28%)
LIMK1	NP_002305.1	LIM1_LIMK1	5..77	CDD:188846
		LIM	84..138	CDD:295319
		PDZ	165..255	CDD:278991
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..319
		STKc_LIMK1	345..611	CDD:271123	76/273 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910