DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and crkl

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_989060.1	Gene:	crkl / 394657	XenbaseID:	XB-GENE-976114	Length:	289	Species:	Xenopus tropicalis

Alignment Length:	345	Identity:	65/345 - (18%)
Similarity:	113/345 - (32%)	Gaps:	116/345 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 WFHGVLPREEVVRLLNND--GDFLVRE--TIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFRFEG 1019
            |:.|.:.|:|....|...  |.||||:  |...:.   ||||..|.. .|:|:.:.....::...
Frog    14 WYFGPVSRQEAQSRLQGQRHGVFLVRDSSTCPGDH---VLSVSENSRVSHYIINSLPGRRYKIGD 75

  Fly  1020 PPFASIQELI-MHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLK 1083
            ..|.::..|: .::.|                        ..|...|:|...|      |.:...
Frog    76 QEFDNLPALLDFYKIH------------------------YLDTTTLIEPAPR------YPSPPV 110

  Fly  1084 STKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHP-NIVKLIGICVQKQPIMIVMELVLGGSLL 1147
            .|....:|     .:|:|.    |:..|.|  ||.| |..:  .:..:|..|::::|
Frog   111 GTGTAPSV-----PVPEEN----LEYVRTL--YDFPGNDAE--DLPFKKGEILVIVE-------- 154

  Fly  1148 TYLRKNSNGLTTRQQMGMCRDAAAGM---RYLE--SKNCIHRDLAARNCLVDLEHSVKISDFGMS 1207
               :......:.|.     :|...||   .|:|  |:..:|..:..||.          :.:|:.
Frog   155 ---KPEEQWWSARN-----KDGRIGMIPVPYVEKLSRLSLHGKMGNRNS----------NSYGIP 201

  Fly  1208 REEEEYIVSDGMKQIPVKWTAPEALNF---------------------GKYTSLCDVWSYGILMW 1251
            .....|........:|...|.|..:.|                     |:...: ::..:|..:|
Frog   202 EPAHAYAQPQTPSPLPASSTPPAVIQFKAGSGAVSGHGSAAIIVLVGDGQILKV-NLSFWGTFLW 265

  Fly  1252 E----IFSKGDTPYSGMTNS 1267
            :    .|.|      ||||:
Frog   266 QAVSFYFCK------GMTNT 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	21/84 (25%)
		TyrKc	1063..1311	CDD:197581	43/236 (18%)
		PTKc_Fes_like	1067..1315	CDD:270637	42/232 (18%)
crkl	NP_989060.1	SH2_CRK_like	6..106	CDD:198180	25/124 (20%)
crkl	NP_989060.1	SH3_CRK_N	126..180	CDD:212692	14/73 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910