DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and grap2b

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_956972.1	Gene:	grap2b / 393651	ZFINID:	ZDB-GENE-040426-1485	Length:	249	Species:	Danio rerio

Alignment Length:	302	Identity:	53/302 - (17%)
Similarity:	103/302 - (34%)	Gaps:	89/302 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 ECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRM----GKNHILNEEQDAKRTQPSQH 744
            |.....|.|.:....|||.:..:..|.....::.::.:..|    .:|:|:.       |.||.:
Zfish     2 EATGKYDFSATAGDELSFRKGDVIKILGTNDDWFRAEINGMEGFVPRNYIVT-------TFPSWY 59

  Fly   745 HHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPS-------K 802
                                  .:|||..|    :|..::...|...|...:.::|.       .
Zfish    60 ----------------------KENTSRQS----AQDELMCQPIGAFIIRGSQSSPGDFSISVRH 98

  Fly   803 ENSRLKFKVPKIQKKSKAIRN---TFRSKLLNFQLKRSKPCKQCTKRRRIH---PSKSVFDFAKE 861
            ||....|||.:.::....:.:   |..:||:::....|     .:|:.|:.   ..:|..||...
Zfish    99 ENDVQHFKVMRDRQGRYYLWSEMFTSLNKLVDYYTHNS-----ISKQSRVFLLTDQRSSSDFLHR 158

  Fly   862 FEVEQPAGSAADEQFCNCPPAGQKPVKPSV--QISG-HKDHPFESSSGELDENSDRDIDNDEEEE 923
            ...|.|......:.:.:..|...:|.:||:  |:|. |....::.::            .|.:|.
Zfish   159 KPTEAPPFRQERQDYRSLAPPVARPSQPSLPPQVSALHVRAMYDFTA------------EDADEL 211

  Fly   924 DSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVL 965
            :..:.||:.:.|..                   :..|:.|||
Zfish   212 NFQAGDVIEVLDQS-------------------DRSWWKGVL 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	4/13 (31%)
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
grap2b	NP_956972.1	SH3	2..51	CDD:302595	9/48 (19%)
		SH2_Grb2_like	54..147	CDD:199828	22/123 (18%)
		SH3	197..248	CDD:302595	9/69 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000