DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and LCK

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_024302814.1	Gene:	LCK / 3932	HGNCID:	6524	Length:	567	Species:	Homo sapiens

Alignment Length:	396	Identity:	140/396 - (35%)
Similarity:	209/396 - (52%)	Gaps:	57/396 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 LYEEEWFHGVLPREEVVRLL----NNDGDFLVRE----------TIRN---EESQIVLSVCWNGH 1002
            |..|.||...|.|::..|.|    |..|.||:||          ::|:   .:.::|
Human   180 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV-------- 236

  Fly  1003 KHFIVQTTGEGNFRFEGP--PFASIQELIMHQYHSELPVTVKSGAILRRPVCR----------ER 1055
            ||:.::....|.| :..|  .|..:.||:.|..::...:..:    |.|| |:          :.
Human   237 KHYKIRNLDNGGF-YISPRITFPGLHELVRHYTNASDGLCTR----LSRP-CQTQKPQKPWWEDE 295

  Fly  1056 WELSNDDVVLLERIGRGNFGDVYKAKLKS-TKLDVAVKTCRM--TLPDEQKRKFLQEGRILKQYD 1117
            ||:..:.:.|:||:|.|.||:|:...... ||  ||||:.:.  ..||    .||.|..::||..
Human   296 WEVPRETLKLVERLGAGQFGEVWMGYYNGHTK--VAVKSLKQGSMSPD----AFLAEANLMKQLQ 354

  Fly  1118 HPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSN-GLTTRQQMGMCRDAAAGMRYLESKNC 1181
            |..:|:|..: |.::||.|:.|.:..|||:.:|:..|. .||..:.:.|....|.||.::|.:|.
Human   355 HQRLVRLYAV-VTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 418

  Fly  1182 IHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVW 1244
            |||||.|.|.||....|.||:|||::|  |:.||...:|.| .|:|||||||:|:|.:|...|||
Human   419 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAK-FPIKWTAPEAINYGTFTIKSDVW 482

  Fly  1245 SYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDE 1309
            |:|||:.||.:.|..||.||||....:.::.||||..|.:.|||:|:||..||....|.||.||.
Human   483 SFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDY 547

  Fly  1310 IYNVVD 1315
            :.:|::
Human   548 LRSVLE 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/102 (25%)
		TyrKc	1063..1311	CDD:197581	108/253 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	108/253 (43%)
LCK	XP_024302814.1	SH3_Lck	123..176	CDD:212938
		SH2_Src_Lck	181..281	CDD:198225	25/112 (22%)
		PTKc_Lck_Blk	295..558	CDD:270652	111/267 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910