DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Ack

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster

Alignment Length:	421	Identity:	115/421 - (27%)
Similarity:	193/421 - (45%)	Gaps:	89/421 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   957 EEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFI----VQTTGEGNFRF 1017
            |..|...:|...::.:.|         :.||::     |.|....|..::    ::..|.|.
  Fly    14 ETAWLEDLLREVQLEQFL---------DRIRDD-----LQVTRLAHFDYVLPDDLERCGLGK--- 61

  Fly  1018 EGPPFASIQELI----MHQYHSEL----------PVTVKSGAILRRPVCRERWELS----NDDVV 1064
              |....:.|.:    .||:...:          |.:.|..:..|........:|:    ..|:.
  Fly    62 --PAIRRLMEAVRKKKAHQWRKNILSKLIGGGKQPSSKKQSSAARESSQGNGTQLTCLIHEKDIT 124

  Fly  1065 LLERIGRGNFGDVYKAKLKSTK----LDVAVKTCR---MTLP---DEQKRKFLQEGRILKQYDHP 1119
            :..::|.|:||.|.:.:..::.    :.||||..:   :|.|   |:    |.:|.:.:...||.
  Fly   125 MGLKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDD----FFREVQAMHALDHA 185

  Fly  1120 NIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAA------------AG 1172
            |:|:|.|: |..||:|::.||...||||..|||            .||..:            .|
  Fly   186 NLVRLYGV-VLSQPMMMITELAERGSLLDTLRK------------QCRHTSLTIIWNWSVQIVTG 237

  Fly  1173 MRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR----EEEEYIVSDGMKQIPVKWTAPEALN 1233
            |.|||.|..:|||||.||.|:...:.:||.|||:.|    |::.|::|: .|::|..|.|||:|.
  Fly   238 MAYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSE-HKKVPFPWCAPESLR 301

  Fly  1234 FGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERID-TGYRMPTPKSTPEEMYRLMLQCW 1297
            |.:::...|.|.:|:.:||:||.|:.|:.|:..|:...:|| .|.|:..|.:.|.::|.:|||||
  Fly   302 FRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCW 366

  Fly  1298 AADAESRPHFDEIYNVVDAL---ILRLDNSH 1325
            ......||.|..:...:.::   ::|...||
  Fly   367 DKTPAERPTFAALKEYLASMSPPVMRASRSH 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/99 (15%)
		TyrKc	1063..1311	CDD:197581	92/274 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	92/274 (34%)
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	13/79 (16%)
		PTKc_Ack_like	128..385	CDD:270636	92/274 (34%)
		UBA_TNK1	1031..1070	CDD:270513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468369
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940