DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and KDR

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_002244.1	Gene:	KDR / 3791	HGNCID:	6307	Length:	1356	Species:	Homo sapiens

Alignment Length:	979	Identity:	217/979 - (22%)
Similarity:	338/979 - (34%)	Gaps:	303/979 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 NELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPA 503
            |..::.|.|||:                              ::...:..|:.:||..
Human   374 NHTIKAGHVLTI------------------------------MEVSERDTGNYTVILT------- 401

  Fly   504 RYEPITNHRLRQAAS-VHYLGEEIATSS-TNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQ 566
              .||:..:.....| |.|:..:|...| .:|.|..:...|| ::.|       .|.|.|.|
Human   402 --NPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQ-TLTC-------TVYAIPPP--- 453

  Fly   567 LTAAVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDR-- 629
                       :||:...:|:::....||.........|.:|...:|..|..  |.|:.:.::
Human   454 -----------HHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGG--NKIEVNKNQFA 505

  Fly   630 -IDELNR-----VLDDRLKRTLQPSDDVNAIESAE---ENHIQTR--KLAKDPDSQTKRSSSSSS 683
             |:..|:     |:.......|...:.||.:...|   ..|: ||  ::...||.|.....|.|.
Human   506 LIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHV-TRGPEITLQPDMQPTEQESVSL 569

  Fly   684 ECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSS 748
            .|.:.:.|                  |.||..:...|                   ||...|
Human   570 WCTADRST------------------FENLTWYKLGP-------------------QPLPIH--- 594

  Fly   749 GSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPK 813
            ..:.||....:.......|....|||                   |........:|:.|:.:...
Human   595 VGELPTPVCKNLDTLWKLNATMFSNS-------------------TNDILIMELKNASLQDQGDY 640

  Fly   814 I----QKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADE 874
            :    .:|:|               ||....:|.|...|:.|:.:       ..:|....|..:.
Human   641 VCLAQDRKTK---------------KRHCVVRQLTVLERVAPTIT-------GNLENQTTSIGES 683

  Fly   875 QFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYC 939
            ...:|..:|    .|..||...|                   ||:...|||.    :.:||
Human   684 IEVSCTASG----NPPPQIMWFK-------------------DNETLVEDSG----IVLKD---- 717

  Fly   940 VPSLAASISLSTNRPLYEEEWFH-----GVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCW 999
                 .:.:|:..|...|:|..:     .||...:|      :..|::.........:|::.|..
Human   718 -----GNRNLTIRRVRKEDEGLYTCQACSVLGCAKV------EAFFIIEGAQEKTNLEIIILVGT 771

  Fly  1000 NGHKHF-------IVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWE 1057
            .....|       |::|....|   .|........::|..  .|||:.....   |.|....:||
Human   772 AVIAMFFWLLLVIILRTVKRAN---GGELKTGYLSIVMDP--DELPLDEHCE---RLPYDASKWE 828

  Fly  1058 LSNDDVVLLERIGRGNFGDVYKAKL-----KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYD 1117
            ...|.:.|.:.:|||.||.|.:|..     .:|...||||..:......:.|..:.|.:||....
Human   829 FPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIG 893

  Fly  1118 HP-NIVKLIGICVQK-QPIMIVMELVLGGSLLTYLRKNSN------------------------- 1155
            |. |:|.|:|.|.:. .|:|:::|....|:|.||||...|
Human   894 HHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVD 958

  Fly  1156 ------GLTTRQQMG--------------------------------MCR--DAAAGMRYLESKN 1180
                  .:|:.|...                                :|.  ..|.||.:|.|:.
Human   959 LKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRK 1023

  Fly  1181 CIHRDLAARNCLVDLEHSVKISDFGMSRE---EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCD 1242
            ||||||||||.|:..::.|||.|||::|:   :.:| |..|..::|:||.|||.:....||...|
Human  1024 CIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY-VRKGDARLPLKWMAPETIFDRVYTIQSD 1087

  Fly  1243 VWSYGILMWEIFSKGDTPYSGM-TNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPH 1306
            |||:|:|:|||||.|.:||.|: .:.....|:..|.||..|..|..|||:.||.||..:...||.
Human  1088 VWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPT 1152

  Fly  1307 FDEI 1310
            |.|:
Human  1153 FSEL 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	17/97 (18%)
		TyrKc	1063..1311	CDD:197581	102/324 (31%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/320 (32%)
KDR	NP_002244.1	Ig	41..109	CDD:299845
		IG_like	231..324	CDD:214653
		Ig1_VEGFR	239..326	CDD:143270
		IG_like	340..417	CDD:214653	11/81 (14%)
		Ig2_VEGFR-2	348..417	CDD:143272	11/81 (14%)
		Ig_2	551..661	CDD:290606	28/183 (15%)
		IG	565..661	CDD:214652	25/169 (15%)
		I-set	667..754	CDD:254352	24/135 (18%)
		IGc2	680..744	CDD:197706	18/99 (18%)
		PTKc_VEGFR2	826..1167	CDD:270681	105/332 (32%)
		Pkinase_Tyr	834..1160	CDD:285015	102/324 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1318
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910