DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and JAK2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001309123.1	Gene:	JAK2 / 3717	HGNCID:	6192	Length:	1132	Species:	Homo sapiens

Alignment Length:	423	Identity:	118/423 - (27%)
Similarity:	188/423 - (44%)	Gaps:	102/423 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   948 SLSTNRPL--YEE-------EWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHK 1003
            :|.:.|.|  ||:       :|       .|:..|:||..|:
Human   756 ALDSQRKLQFYEDRHQLPAPKW-------AELANLINNCMDY----------------------- 790

  Fly  1004 HFIVQTTGEGNFRFEGPPFASI----QELIMHQY----HSELPVTVKSGAI-------LRRPVCR 1053
                    |.:||   |.|.:|    ..|....|    .:::...::.||:       .|.|...
Human   791 --------EPDFR---PSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQF 844

  Fly  1054 ERWELSNDDVVLLERIGRGNFGDV----YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILK 1114
            |...|.     .|:::|:||||.|    |.....:|...||||..:.: .:|..|.|.:|..|||
Human   845 EERHLK-----FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS-TEEHLRDFEREIEILK 903

  Fly  1115 QYDHPNIVKLIGICVQ--KQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLE 1177
            ...|.||||..|:|..  ::.:.::||.:..|||..||:|:...:...:.:........||.||.
Human   904 SLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLG 968

  Fly  1178 SKNCIHRDLAARNCLVDLEHSVKISDFGMSR---EEEEYIVSDGMKQIPVKWTAPEALNFGKYTS 1239
            :|..||||||.||.||:.|:.|||.|||:::   :::||.......:.|:.|.|||:|...|::.
Human   969 TKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSV 1033

  Fly  1240 LCDVWSYGILMWEIFS---KGDTP---YSGMTNSRAR---------ERIDTGYRMPTPKSTPEEM 1289
            ..||||:|::::|:|:   |..:|   :..|..:..:         |.:....|:|.|...|:|:
Human  1034 ASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEI 1098

  Fly  1290 YRLMLQCWAADAESRPHFDEIYNVVDALILRLD 1322
            |.:|.:||..:...||.|.:       |.||:|
Human  1099 YMIMTECWNNNVNQRPSFRD-------LALRVD 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/102 (18%)
		TyrKc	1063..1311	CDD:197581	89/271 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	88/271 (32%)
JAK2	NP_001309123.1	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..239
		B41	38..270	CDD:214604
		FERM_C_JAK2	266..386	CDD:270141
		SH2_Jak2	386..482	CDD:198242
		PTK_Jak2_rpt1	545..806	CDD:270663	17/90 (19%)
		Pkinase_Tyr	545..805	CDD:285015	17/89 (19%)
		PTKc_Jak2_rpt2	844..1127	CDD:271107	95/294 (32%)
		TyrKc	849..1119	CDD:197581	90/282 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810