DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Ptk6

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001102438.1	Gene:	Ptk6 / 366275	RGDID:	1309098	Length:	451	Species:	Rattus norvegicus

Alignment Length:	391	Identity:	135/391 - (34%)
Similarity:	208/391 - (53%)	Gaps:	24/391 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   949 LSTNRPLYEEEWFHGVLPREEVVRLLNND----GDFLVRETIRNEESQIVLSVCWNGH--KHFIV 1007
            |:....:..|.||.|.:.|.|.:..|.::    |.||:|.: :...:..|||| |:..  :|:.:
  Rat    67 LAEKETVESEPWFFGCISRSEAMHRLQSEDYPKGTFLIRVS-QKPGADYVLSV-WDAEAVRHYRI 129

  Fly  1008 QTTGEGNFRF-EGPPFASIQELI-MHQYHSELP---VTVKSGAILRRPVCR-ERWELSNDDVVLL 1066
            .....|.... |...|:|:.||: .|:.|:..|   :::....:...|:.. :.||...::..|.
  Rat   130 WRNSAGRLHLNEVVSFSSLSELVNYHKTHNLSPGLQLSMACWKLKTEPLPHWDDWERPREEFTLC 194

  Fly  1067 ERIGRGNFGDVYKAKLKSTKLDVAVKT-CRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQ 1130
            :::|.|.||:|::...|.. :.||||. .|..|  ..:..|..|.:.:|:..|.:|:.|..:...
  Rat   195 KKLGSGYFGEVFEGLWKGL-VRVAVKVISRDNL--LHQHTFQAEIQAMKKLRHKHILSLYAVATA 256

  Fly  1131 KQPIMIVMELVLGGSLLTYLR-KNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVD 1194
            ..|:.|:.||:..||||..|| .:...|...:.:......|.||.||||:|.|||||||||.||.
  Rat   257 GDPVYIITELMPKGSLLQLLRDSDEKDLPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVT 321

  Fly  1195 LEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKG 1257
            ..:..|:.|||::|  :|:.|:..|  ..:|.||||||||:.|.|:...||||:|:|:.||||:|
  Rat   322 ENNLCKVGDFGLARLVKEDIYLSRD--HNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRG 384

  Fly  1258 DTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLD 1322
            ..||.||:|.....|:|.|||||.|...|..:::|||.||:.|.:.||.|.::...:.. |.|.:
  Rat   385 QMPYPGMSNHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKLSG-ITRYE 448

  Fly  1323 N 1323
            |
  Rat   449 N 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	26/96 (27%)
		TyrKc	1063..1311	CDD:197581	102/251 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/251 (40%)
Ptk6	NP_001102438.1	SH3_Brk	12..69	CDD:212781	1/1 (100%)
		SH2_PTK6_Brk	75..174	CDD:198221	26/100 (26%)
		PKc_like	184..444	CDD:304357	104/265 (39%)
		STYKc	192..441	CDD:214568	102/253 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910