DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Blk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_006252250.1	Gene:	Blk / 364403	RGDID:	1308859	Length:	554	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	150/488 - (30%)
Similarity:	234/488 - (47%)	Gaps:	83/488 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   880 PPAGQKPVKPSVQISGHKDHPFESSSGELDEN-----------SDRDIDNDEEEE----DSASDD 929
            ||    |:.|.| :..|...|..:...:.:|.           :|||:...:.|:    .|..|.
  Rat    84 PP----PLPPLV-VFNHLPPPSPNQHPDEEERFVVALFDYAAVNDRDLQVLKGEKLQVLKSTGDW 143

  Fly   930 VLSMKDHCYCVPSLAASISLSTNRPLY-------------EEEWFHGVLPREEVVRLL----NND 977
            .|:.              ||.|.|..|             .|:||...:.|::..|.|    |..
  Rat   144 WLAR--------------SLVTGREGYVPSNFVAPVETLEVEKWFFRTISRKDAERQLLAPMNKA 194

  Fly   978 GDFLVRETIRNEE--SQIVLSVCWNGH--KHFIVQTTGEGNFRFEGP--PFASIQELIMHQYHSE 1036
            |.||:||:..|:.  |..|..|...|.  ||:.:::...|.: :..|  .|.::|.|:.|  :||
  Rat   195 GSFLIRESESNKGAFSLSVKDVTSQGEMVKHYKIRSLDNGGY-YISPRITFPTLQALVQH--YSE 256

  Fly  1037 ----------LPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAV 1091
                      ||..   ....:.|..::.||:....:.|:.::|.|.||:|:....|: .:.||:
  Rat   257 KGDGLCQKLTLPCV---NPAPKNPWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKN-NMKVAI 317

  Fly  1092 KTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSN 1155
            ||.:. |:..|   .||.|..::|...|..:|:|..: |.::||.||.|.:..|.||.:|:.:..
  Rat   318 KTLKEGTMSPE---AFLGEANVMKTLQHERLVRLYAV-VTREPIYIVTEYMARGCLLDFLKTDEG 378

  Fly  1156 G-LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-EEEEYIVSDG 1218
            . |:..:.:.|....|.||.|:|..|.|||||.|.|.||......||:|||::| .:.||...:|
  Rat   379 SRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEG 443

  Fly  1219 MKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPK 1283
            .| .|:|||||||::||.:|...||||:|:|:.||.:.|..||.||:|......::.|||||.|:
  Rat   444 AK-FPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPE 507

  Fly  1284 STPEEMYR-LMLQCWAADAESRPHFDEIYNVVD 1315
            :.|.|:|. ::.:||....|.||.|:.:.:|::
  Rat   508 TCPPELYHDVITECWRGRPEERPTFEFLQSVLE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/118 (25%)
		TyrKc	1063..1311	CDD:197581	97/251 (39%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/251 (39%)
Blk	XP_006252250.1	SH3	111..164	CDD:302595	12/66 (18%)
		SH2	169..268	CDD:301589	27/101 (27%)
		PKc_like	282..545	CDD:304357	100/265 (38%)
		Pkinase_Tyr	290..539	CDD:285015	97/254 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910