Protein Alignment FER and Blk

DIOPT Version :10

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_006252250.1
• Gene: Blk / 364403
• RGDID: 1308859
• Length: 554
• Species: Rattus norvegicus
• Alignment Length: 488
• Identity: 150/488 - (30%)
• Similarity: 234/488 - (47%)
• Gaps: 83/488 - (17%)

  Fly   880 PPAGQKPVKPSVQISGHKDHPFESSSGELDEN-----------SDRDIDNDEEEE----DSASDD 929
            ||    |:.|.| :..|...|..:...:.:|.           :|||:...:.|:    .|..|.
  Rat    84 PP----PLPPLV-VFNHLPPPSPNQHPDEEERFVVALFDYAAVNDRDLQVLKGEKLQVLKSTGDW 143

  Fly   930 VLSMKDHCYCVPSLAASISLSTNRPLY-------------EEEWFHGVLPREEVVRLL----NND 977
            .|:.              ||.|.|..|             .|:||...:.|::..|.|    |..
  Rat   144 WLAR--------------SLVTGREGYVPSNFVAPVETLEVEKWFFRTISRKDAERQLLAPMNKA 194

  Fly   978 GDFLVRETIRNEE--SQIVLSVCWNGH--KHFIVQTTGEGNFRFEGP--PFASIQELIMHQYHSE 1036
            |.||:||:..|:.  |..|..|...|.  ||:.:::...|.: :..|  .|.::|.|:.|  :||
  Rat   195 GSFLIRESESNKGAFSLSVKDVTSQGEMVKHYKIRSLDNGGY-YISPRITFPTLQALVQH--YSE 256

  Fly  1037 ----------LPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAV 1091
                      ||..   ....:.|..::.||:....:.|:.::|.|.||:|:....|: .:.||:
  Rat   257 KGDGLCQKLTLPCV---NPAPKNPWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKN-NMKVAI 317

  Fly  1092 KTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSN 1155
            ||.:. |:..|   .||.|..::|...|..:|:|..: |.::||.||.|.:..|.||.:|:.:..
  Rat   318 KTLKEGTMSPE---AFLGEANVMKTLQHERLVRLYAV-VTREPIYIVTEYMARGCLLDFLKTDEG 378

  Fly  1156 G-LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-EEEEYIVSDG 1218
            . |:..:.:.|....|.||.|:|..|.|||||.|.|.||......||:|||::| .:.||...:|
  Rat   379 SRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEG 443

  Fly  1219 MKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPK 1283
            .| .|:|||||||::||.:|...||||:|:|:.||.:.|..||.||:|......::.|||||.|:
  Rat   444 AK-FPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPE 507

  Fly  1284 STPEEMYR-LMLQCWAADAESRPHFDEIYNVVD 1315
            :.|.|:|. ::.:||....|.||.|:.:.:|::
  Rat   508 TCPPELYHDVITECWRGRPEERPTFEFLQSVLE 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/118 (25%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/251 (39%)
Blk	XP_006252250.1	SH3	111..164	CDD:473055	12/66 (18%)
		SH2	169..268	CDD:472789	27/101 (27%)
		Protein Kinases, catalytic domain	282..545	CDD:473864	100/265 (38%)