DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Drl-2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	313	Identity:	88/313 - (28%)
Similarity:	136/313 - (43%)	Gaps:	39/313 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1009 TTGEGNFR-FEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRG 1072
            |:|.|:.. |.|.|..|   .|....|.|     |....|||....:...||.:::|     ..|
  Fly   339 TSGSGSLSLFGGIPTGS---TITMASHGE-----KGNQRLRRITSVQPGALSYEELV-----KEG 390

  Fly  1073 NFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIV 1137
            .||.:|..|| ....:..|||........|....||:..:|....|.:|:         .|::..
  Fly   391 TFGRIYAGKL-GESCEALVKTVIDGASLTQVACLLQDASLLIGVSHQHIL---------APLLAN 445

  Fly  1138 MEL----------VLGGSLLTYL---RKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAAR 1189
            .||          ...|:|..||   |::|..|:|||.:........|:.||.|...:|:|:|.|
  Fly   446 TELPGPPEIAYPHPSKGNLKMYLQKSRESSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATR 510

  Fly  1190 NCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWE 1252
            ||.:|.|..|||.|..:||:  .::|......:..|:||.:.|:|....|.:..|||:.|:..||
  Fly   511 NCYLDEESYVKICDSALSRDLFPDDYDCLGDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWE 575

  Fly  1253 IFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRP 1305
            :.:....|:..:........:..|:|:..|.:.|:|.:.:|..||..:|:.||
  Fly   576 LVTLAQMPHEEVDIFELTNYLAAGFRLEQPVNCPDEFFTVMNCCWHCEAKQRP 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	10/30 (33%)
		TyrKc	1063..1311	CDD:197581	72/258 (28%)
		PTKc_Fes_like	1067..1315	CDD:270637	71/254 (28%)
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237
		PTK_Ryk	373..644	CDD:270639	74/271 (27%)
		STYKc	389..637	CDD:214568	71/250 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910