DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and INSR

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_000199.2	Gene:	INSR / 3643	HGNCID:	6091	Length:	1382	Species:	Homo sapiens

Alignment Length:	1122	Identity:	263/1122 - (23%)
Similarity:	438/1122 - (39%)	Gaps:	287/1122 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 TVDNLTVDWLRNRLQELEGAVRDCQEKQMKMIEHVNGGSPVANGSIISN---GSNTSNGIQSNKD 363
            |:|::|      ..|||.|..                   |.|||:|.|   |:|.:..:::|..
Human   347 TIDSVT------SAQELRGCT-------------------VINGSLIINIRGGNNLAAELEANLG 386

  Fly   364 SL--------CRQSKDL------NALRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQN 414
            .:        .|:|..|      ..||....:..::.:....||:.....:|......:||:.|.
Human   387 LIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQG 451

  Fly   415 FIENGYN------------------NEQQRSN---STSSPGLGIMNELMRRGGVLT-----LLRG 453
            .:...||                  ..|:|::   .|:.......|||::...:.|     |||.
Human   452 KLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRW 516

  Fly   454 RGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAAS 518
                       :|..|..      |..|      ||.:...::      |.|:.:|
Human   517 -----------EPYWPPD------FRDL------LGFMLFYKE------APYQNVT--------- 543

  Fly   519 VHYLGEEIATSST------NPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQ---LTAAVLTN 574
             .:.|::...|::      :||    ||.....    .::....::....|.||   ....::|.
Human   544 -EFDGQDACGSNSWTVVDIDPP----LRSNDPK----SQNHPGWLMRGLKPWTQYAIFVKTLVTF 599

  Fly   575 TNNNHIY---ADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTA-PQNSIDAHL---DRIDE 632
            ::....|   :|:...:...|:||.......:.....||.::....: |..:|..:|   :|..|
Human   600 SDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAE 664

  Fly   633 LNRV--LDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSS---SSSSECRSSKDTS 692
            .:.:  ||..||....||...:....:|             |||....|   .|:.||.|...|.
Human   665 DSELFELDYCLKGLKLPSRTWSPPFESE-------------DSQKHNQSEYEDSAGECCSCPKTD 716

  Fly   693 HSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSS 757
                          |.|   |||..:|...:..::::.|.....::|.     ..:|::.|..|.
Human   717 --------------SQI---LKELEESSFRKTFEDYLHNVVFVPRKTS-----SGTGAEDPRPSR 759

  Fly   758 SSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTP-SKENSRLKFKVPKIQKKSKAI 821
            ...|..:..|             .|:...|:.....|::|:.| |.|..|...||  :.|:|..|
Human   760 KRRSLGDVGN-------------VTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKV--VNKESLVI 809

  Fly   822 RNTFRSKLLNFQLKR--SKPCKQCTKRRRIHPSKSVFDFAK---EFEVEQPAGSAADEQFCN--C 879
                 |.|.:|...|  .:.|.|.|...|.  |.:.:..|:   |.:.:...|....|.|.|  .
Human   810 -----SGLRHFTGYRIELQACNQDTPEERC--SVAAYVSARTMPEAKADDIVGPVTHEIFENNVV 867

  Fly   880 PPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHC------- 937
            ....|:|.:|:..|             .|.|.|.|.. .|||.....|....:::..|
Human   868 HLMWQEPKEPNGLI-------------VLYEVSYRRY-GDEELHLCVSRKHFALERGCRLRGLSP 918

  Fly   938 --YCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVL----- 995
              |.|...|.  ||:.|....|..:|:..              |:|   .:.:..::|::
Human   919 GNYSVRIRAT--SLAGNGSWTEPTYFYVT--------------DYL---DVPSNIAKIIIGPLIF 964

  Fly   996 ----SVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSE---LPVTVKSGAILRRPVCR 1053
                ||.......|:.:...:|..   ||.:||...    :|.|.   .|.:|         ...
Human   965 VFLFSVVIGSIYLFLRKRQPDGPL---GPLYASSNP----EYLSASDVFPCSV---------YVP 1013

  Fly  1054 ERWELSNDDVVLLERIGRGNFGDVYKAKLK-----STKLDVAVKTCRMTLPDEQKRKFLQEGRIL 1113
            :.||:|.:.:.||..:|:|:||.||:...:     ..:..|||||...:....::.:||.|..::
Human  1014 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVM 1078

  Fly  1114 KQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR------KNSNGL---TTRQQMGMCRDA 1169
            |.:...::|:|:|:..:.||.::||||:..|.|.:|||      :|:.|.   |.::.:.|..:.
Human  1079 KGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEI 1143

  Fly  1170 AAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEAL 1232
            |.||.||.:|..:|||||||||:|..:.:|||.||||:|:  |.:|....|...:||:|.|||:|
Human  1144 ADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESL 1208

  Fly  1233 NFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCW 1297
            ..|.:|:..|:||:|:::|||.|..:.||.|::|.:..:.:..|..:..|.:.||.:..||..||
Human  1209 KDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCW 1273

  Fly  1298 AADAESRPHFDEIYNVV 1314
            ..:.:.||.|.||.|::
Human  1274 QFNPKMRPTFLEIVNLL 1290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/97 (15%)
		TyrKc	1063..1311	CDD:197581	95/263 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	95/264 (36%)
INSR	NP_000199.2	Recep_L_domain	52..164	CDD:279382
		Furin-like	179..337	CDD:279142
		FU	234..281	CDD:238021
		Recep_L_domain	359..472	CDD:279382	23/131 (18%)
		FN3	622..>665	CDD:238020	8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	686..708		6/34 (18%)
		Insulin-binding	733..741		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..766		5/24 (21%)
		FN3	867..944	CDD:238020	21/92 (23%)
		PTKc_InsR	1016..1303	CDD:133192	100/275 (36%)
		Pkinase_Tyr	1023..1290	CDD:285015	97/266 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1360..1382
		PIK3R1-binding	1361..1364
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910