Protein Alignment FER and Itk

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_001102295.2
• Gene: Itk / 363577
• RGDID: 1311618
• Length: 620
• Species: Rattus norvegicus
• Alignment Length: 650
• Identity: 183/650 - (28%)
• Similarity: 288/650 - (44%)
• Gaps: 110/650 - (16%)

  Fly   727 NHILNEEQDAKRTQPSQHHHSSGSDCP------TNSSSSSSNNNNNNKNTSSNSNHSASQS--TI 783
            |.||.|||..|::|  |...:|.|:..      |.:|.:...:.:..|.|...|...:...  .|
  Rat     3 NFILLEEQLIKKSQ--QKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEI 65

  Fly   784 ITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAI---------RNTFRSKL-LNFQLKRSK 838
            :.|.|:.............:|..|....|..:.:.:.:         .|:..||. .||.:....
  Rat    66 VKSDISIPCHYKYPFQVMHDNYLLYVFAPDCESRQRWVLTLKEETRNNNSLVSKYHPNFWMDGRW 130

  Fly   839 PCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHK-DHPFE 902
            .|  |::..::....:.:|..|.                    |.:||:.|:.:.:... ..|.|
  Rat   131 RC--CSQLEKLAVGCAPYDPTKN--------------------ASKKPLPPTPEDNRRSFQEPEE 173

  Fly   903 S---SSGELDENSDRDIDNDEEEE----DSASDDVLSMKD---HCYCVPSLAASISLSTNRPLYE 957
            :   :..:...|..:::....:||    ||:......::|   |....|| :..:..|.| .|..
  Rat   174 TLVIALYDYQTNDPQELALRRDEEYYLLDSSEIHWWRVQDKNGHEGYAPS-SYLVEKSPN-SLET 236

  Fly   958 EEWFHGVLPREEVVRLL---NNDGDFLVRET--------------IRNEESQIVLSVCWNGHKHF 1005
            .||::..:.|::..:||   ..:|.|:||::              |.:|.:..:        ||:
  Rat   237 YEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTPGTYTVSVFTKAIISENNPCI--------KHY 293

  Fly  1006 IVQTTGEGNFRF---EGPPFASIQELIM-HQYHSELPVTVKSGAILRRPVCRER----------- 1055
            .::.|.:...|:   |...|.||..||. |||:....||     .||.|||..|
  Rat   294 HIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYNGGGLVT-----RLRYPVCSWRQKAPVTAGLRY 353

  Fly  1056 --WELSNDDVVLLERIGRGNFGDVYKAK-LKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYD 1117
              |.:...::..::.||.|.||.|:... |...|  ||:||.:.....|:  .|::|..::.:..
  Rat   354 GKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDK--VAIKTIQEGAMSEE--DFIEEAEVMMKLS 414

  Fly  1118 HPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCI 1182
            ||.:|:|.|:|:::.||.:|.|.:..|.|..|||...........:|||.|...||.|||....|
  Rat   415 HPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKACVI 479

  Fly  1183 HRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWS 1245
            |||||||||||.....:|:|||||:|  .:::|..|.|.| .||||.:||..:|.:|:|..||||
  Rat   480 HRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTK-FPVKWASPEVFSFSRYSSKSDVWS 543

  Fly  1246 YGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            :|:||||:||:|..||...:||...|.|.||:|:..|:.....:|::|..||....|.||.|..:
  Rat   544 FGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASPHVYQVMNHCWKEKPEDRPPFSRL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/106 (24%)
		TyrKc	1063..1311	CDD:197581	101/250 (40%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/246 (41%)
Itk	NP_001102295.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910