Protein Alignment FER and IGF1R

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_016877625.1
• Gene: IGF1R / 3480
• HGNCID: 5465
• Length: 1392
• Species: Homo sapiens
• Alignment Length: 1439
• Identity: 288/1439 - (20%)
• Similarity: 484/1439 - (33%)
• Gaps: 505/1439 - (35%)

  Fly   171 DVRDKYQKACRKLHLTHNE---YVLSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQ 232
            |:|:.||:..|..:.|..|   ::|.|::|    :|:|:...|.|     :|...::||:|  :.
Human    63 DIRNDYQQLKRLENCTVIEGYLHILLISKA----EDYRSYRFPKL-----TVITEYLLLFR--VA 116

  Fly   233 EAAQYGD----LTADKYKEIQKRIDTVIGSINPTEEYGEFTEKYKTSPTTPL--------LFQFD 285
            .....||    ||..:..::......||..:...::.|.:..:..|.....:        |...|
Human   117 GLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVD 181

  Fly   286 ETLIQD-------------------IPGKLQSSTLTVDNLTVD-------WLRNRLQELEGAV-- 322
            .:||.|                   .||.::...: .:..|::       |..||.|::..:.
Human   182 WSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPM-CEKTTINNEYNYRCWTTNRCQKMCPSTCG 245

  Fly   323 -RDCQEKQMKMIEHVNGGSPVAN---------------------------------------GSI 347
             |.|.|..........|.....:                                       .:|
Human   246 KRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANI 310

  Fly   348 ISNGSNTSNGIQSNKDSLCRQSKDLNALR------------------CQEKQKQKLVDMIKCALN 394
            :|..|:.|.|...: |..|.|......:|                  |:|::|.|.:|.:..|
Human   311 LSAESSDSEGFVIH-DGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSA-- 372

  Fly   395 EVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTLLRG--RGRH 457
                 ::..||   ...:.|.:.|     .:|.|:       |.:||....|::.::.|  :.||
Human   373 -----QMLQGC---TIFKGNLLIN-----IRRGNN-------IASELENFMGLIEVVTGYVKIRH 417

  Fly   458 FKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIR-----------DGN------------- 498
                                       |.:|.|||.::           :||
Human   418 ---------------------------SHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQ 455

  Fly   499 --------------------GPSPA-----RYEPITNHRLRQAAS-----------------VHY 521
                                .|...     |.|.:|..:.||:..                 :|:
Human   456 LWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHF 520

  Fly   522 LGEEIATSSTN----------PPDLTRL-------------------RRTQCSM---------LC 548
            ..   .|:|.|          |||...|                   .:..|..         |.
Human   521 TS---TTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLP 582

  Fly   549 LGEDEEP-VVLASPAPLTQ----LTAAVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKE 608
            ..:|.|| ::|....|.||    :.|..||...|:||                  :|    .|.|
Human   583 PNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHI------------------RG----AKSE 625

  Fly   609 QIRIEINQTAPQNSIDAHLDRIDELNRVL-------------------------DDRLKRTLQPS 648
            .:.|..|.:.|...:|. |...:..::::                         |..|.|....|
Human   626 ILYIRTNASVPSIPLDV-LSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCS 689

  Fly   649 DDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNL 713
            .|...|....:..|...::.::|  :|:........|.:...|...|:...  .:.....:|.|.
Human   690 KDKIPIRKYADGTIDIEEVTENP--KTEVCGGEKGPCCACPKTEAEKQAEK--EEAEYRKVFENF 750

  Fly   714 KEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSA 778
            ..           |.|.....:.||....|         ..|::.||.:.|
Human   751 LH-----------NSIFVPRPERKRRDVMQ---------VANTTMSSRSRN-------------- 781

  Fly   779 SQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQC 843
                      ||...|...|.|.:..:...|...::..|.:    |..|.|..|.|.|..
Human   782 ----------TTAADTYNITDPEELETEYPFFESRVDNKER----TVISNLRPFTLYRID----- 827

  Fly   844 TKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGEL 908
                 ||        :...|.|:...||::..|....||           .|..|.|...:....
Human   828 -----IH--------SCNHEAEKLGCSASNFVFARTMPA-----------EGADDIPGPVTWEPR 868

  Fly   909 DENSDRDIDNDEEEEDSASDDVL--------SMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVL 965
            .|||   |.....|.::.:..:|        .::|...||           :|..|.:  :.|.
Human   869 PENS---IFLKWPEPENPNGLILMYEIKYGSQVEDQRECV-----------SRQEYRK--YGGA- 916

  Fly   966 PREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQT-TGEGNFRF------------ 1017
               ::.||  |.|::    |.|.:.:.:..:..|.....|.||. ||..||..
Human   917 ---KLNRL--NPGNY----TARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLI 972

  Fly  1018 ---------------------EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSND 1061
                                 .|..:||:..    :|.|...|.|.           :.||::.:
Human   973 VGGLVIMLYVFHRKRNNSRLGNGVLYASVNP----EYFSAADVYVP-----------DEWEVARE 1022

  Fly  1062 DVVLLERIGRGNFGDVYKAKLKSTKLD-----VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNI 1121
            .:.:...:|:|:||.||:...|....|     ||:||........::.:||.|..::|:::..::
Human  1023 KITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHV 1087

  Fly  1122 VKLIGICVQKQPIMIVMELVLGGSLLTYLR------KNSNGL---TTRQQMGMCRDAAAGMRYLE 1177
            |:|:|:..|.||.:::|||:..|.|.:|||      :|:..|   :..:.:.|..:.|.||.||.
Human  1088 VRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLN 1152

  Fly  1178 SKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSL 1240
            :...:|||||||||:|..:.:|||.||||:|:  |.:|....|...:||:|.:||:|..|.:|:.
Human  1153 ANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTY 1217

  Fly  1241 CDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRP 1305
            .||||:|:::|||.:..:.||.|::|.:....:..|..:..|.:.|:.::.||..||..:.:.||
Human  1218 SDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRP 1282

  Fly  1306 HFDEIYNVV 1314
            .|.||.:.:
Human  1283 SFLEIISSI 1291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	22/78 (28%)
		SH2_Fps_family	953..1039	CDD:198224	22/119 (18%)
		TyrKc	1063..1311	CDD:197581	90/263 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	91/264 (34%)
IGF1R	XP_016877625.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910