Protein Alignment FER and Btk29A

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_001097121.1
• Gene: Btk29A / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 178/629 - (28%)
• Similarity: 285/629 - (45%)
• Gaps: 146/629 - (23%)

  Fly   764 NNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSK 828
            |||..|.||.:.:|           |.:|:..::||.|:
  Fly   227 NNNPSNGSSPAQNS-----------TRSISPNSSTTNSQ-------------------------- 254

  Fly   829 LLNFQLKRSKPCK-------------------------QCTKRRRIHPSKSVFDFAKEFEVEQPA 868
               |.|:.:....                         .||. ..:.|..|:..|.:...:....
  Fly   255 ---FSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTP-TSLQPQSSLTTFKQSPTLLNGN 315

  Fly   869 GSAADEQFCNCPPAGQKPVKPSVQISGHKD-----------HPFESSSG---ELDENSDRDIDND 919
            |:..|   .|.|.....|..|:   |..||           :||::..|   .|::|::.::.:|
  Fly   316 GTLLD---ANMPGGIPTPGTPN---SKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDD 374

  Fly   920 EEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRP-----LYEEEWFHGVLPREEVVRLL---NN 976
            .:|......|.|....:   :||       :..:|     |...||:.|.:.|:....||   :.
  Fly   375 SQEHWWKVKDALGNVGY---IPS-------NYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDK 429

  Fly   977 DGDFLVRETIRNEESQIVLSVCWNGH--------KHFIVQTTGEGNFRF-EGPPFASIQELIMHQ 1032
            :|.|:||::  :.:....||:    |        ||:.::......:.. |.....:|.:||.:.
  Fly   430 EGCFVVRKS--STKGLYTLSL----HTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYH 488

  Fly  1033 YHSE--LPVTVKSGAILRRPV------CRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDV 1089
            .|:.  |...:||.. ..|||      ..::||:...:::|:|.:|.|.||.|.:.|.:.: :|.
  Fly   489 RHNSGGLACRLKSSP-CDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGS-IDT 551

  Fly  1090 AVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN 1153
            |||..:. |:.::.   |::|.:::.:..|||:|:|.|:|.:.:||.||.|.:..||||.|||::
  Fly   552 AVKMMKEGTMSEDD---FIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRH 613

  Fly  1154 SNGLTTRQQMG----MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEE 1212
            ..  |....||    ||...:.||.|||..|.||||||||||||..|:.||::|||::|.  :::
  Fly   614 EK--TLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ 676

  Fly  1213 YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGY 1277
            |..|.|.| .|:||..||.||:.:::|..|||:||:||||||:.|..||..:.|:...||:..|.
  Fly   677 YTSSGGTK-FPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGI 740

  Fly  1278 RMPTPKSTPEEMYRLMLQCWAADAESRPHF----DEIYNVVDAL 1317
            .:..|||..:|:|.:|..||:...|.||.|    |::..|...|
  Fly   741 ILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTL 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/104 (22%)
		TyrKc	1063..1311	CDD:197581	107/258 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	107/258 (41%)
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	11/62 (18%)
		SH2_Tec_family	403..505	CDD:198188	24/108 (22%)
		PTKc_Tec_like	521..778	CDD:173637	107/263 (41%)
		Pkinase_Tyr	526..777	CDD:285015	107/257 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468344
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950