DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Map3k9

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_017170611.1	Gene:	Map3k9 / 338372	MGIID:	2449952	Length:	1120	Species:	Mus musculus

Alignment Length:	431	Identity:	115/431 - (26%)
Similarity:	181/431 - (41%)	Gaps:	88/431 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   909 DENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRL 973
            |:.:....:.:|:||::|::    :..|. .:|...|......   ..|:|.   .|...:||.:
Mouse    21 DDATGAGAEEEEDEEEAAAE----LGSHA-ALPYWTAVFEYEA---AGEDEL---TLRLGDVVEV 74

  Fly   974 LNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTG--EGNFRFEGPPFASIQELIMHQYHSE 1036
            |:.|..      :..:|.      .|.|.   :.|..|  ..|:......|:|
Mouse    75 LSKDSQ------VSGDEG------WWTGQ---LNQRVGIFPSNYVTPRSAFSS------------ 112

  Fly  1037 LPVTVKSGAILRRPVCR---ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTL 1098
               ..:.||  ..|.|.   :..|:...::.|.|.||.|.||.||:|.....  :||||..|..
Mouse   113 ---RCQPGA--EDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWAGD--EVAVKAARHD- 169

  Fly  1099 PDEQKRKFL----QEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTT 1159
            |||...:.:    ||.::.....||||:.|.|:|:::..:.:|||...||.|...|  :...:..
Mouse   170 PDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL--SGKRIPP 232

  Fly  1160 RQQMGMCRDAAAGMRYLESK---NCIHRDLAARNCLV-------DLEHSV-KISDFGMSRE--EE 1211
            ...:......|.||.||..:   ..|||||.:.|.|:       ||.:.: ||:|||::||  ..
Mouse   233 DILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRT 297

  Fly  1212 EYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTG 1276
            ..:.:.|    ...|.|||.:....::...||||||:|:||:.: |:.|:.|:      :.:...
Mouse   298 TKMSAAG----TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGI------DGLAVA 351

  Fly  1277 Y-------RMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            |       .:|.|.:.||...:||..||..|..|||.|..|
Mouse   352 YGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTSI 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/87 (17%)
		TyrKc	1063..1311	CDD:197581	87/272 (32%)
		PTKc_Fes_like	1067..1315	CDD:270637	86/268 (32%)
Map3k9	XP_017170611.1	SH3_MLK1-3	49..106	CDD:212992	14/77 (18%)
Map3k9	XP_017170611.1	STKc_MLK1	130..399	CDD:271047	88/279 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900