DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and yrk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001352482.1	Gene:	yrk / 337571	ZFINID:	ZDB-GENE-030131-9517	Length:	528	Species:	Danio rerio

Alignment Length:	563	Identity:	168/563 - (29%)
Similarity:	258/563 - (45%)	Gaps:	117/563 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   813 KIQKKSKAIRN----------------------TFRSKLLNFQLKRSKPCKQCTKRRRIHPSK-- 853
            |.:|.|||:.|                      ||.|.:.||. ..|.|....|.  .|:|::
Zfish     7 KQRKASKAVSNQNSCDAFNGTQASEPSRYIPDPTFNSGIPNFN-DFSNPLTPPTS--IINPARPP 68

  Fly   854 -----SVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSD 913
                 .|..|...:|.:  |.:..|..|       ||         |.|.|...::.|:..|  .
Zfish    69 GLTGGGVTLFIALYEYD--ARTEDDLSF-------QK---------GEKFHIINNTEGDWWE--A 113

  Fly   914 RDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLL---- 974
            |.:|..:..               |...:..|.:.     .:..|||:.|.:.|::..|.|
Zfish   114 RSLDTGKSG---------------YIPSNYVAPVD-----SIQAEEWYFGKMGRKDAERQLLAQN 158

  Fly   975 NNDGDFLVRETIRNEESQIVLSVCWN----GH-KHFIVQTTGEGNFRF-EGPPFASIQELIMHQY 1033
            |..|.||:||:...:.:..:....|:    .| ||:.::....|.:.. ....|.::|:|:.|
Zfish   159 NPRGTFLIRESETTKGAYSLSIRDWDDAKGDHVKHYKIRKLDNGGYYITTRTQFDTVQQLVEH-- 221

  Fly  1034 HSELPVTVKSGAILRRPV--CR--------------ERWELSNDDVVLLERIGRGNFGDVYKAKL 1082
                 .|.::..:..|.:  ||              :.||:..:.:.|::::|.|.||:|:....
Zfish   222 -----YTERAAGLCCRLIGSCRRGMPKLADLSVKTKDVWEIPRESLQLIKKLGNGQFGEVWMGMW 281

  Fly  1083 KSTKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSL 1146
            ..| ..|||||.:. |:..|   .||.|.:|:|:..|..:|:|..: |.::||.|:.|.:..|||
Zfish   282 NGT-TKVAVKTLKPGTMSPE---AFLDEAQIMKRLRHDKLVQLYAV-VSEEPIYIITEFMSQGSL 341

  Fly  1147 LTYLRKNSNG--LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR- 1208
            |.:| |:.:|  |...|.:.|....||||.|:|..|.|||||.|.|.||......||:|||::|
Zfish   342 LDFL-KDGDGRNLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDGLVCKIADFGLARL 405

  Fly  1209 -EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARER 1272
             |:.||....|.| .|:|||||||..:||:|...||||:|||:.|:.:||..||.||.|....|:
Zfish   406 IEDNEYTARQGAK-FPIKWTAPEAALYGKFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQ 469

  Fly  1273 IDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVD 1315
            ::.|||||.|:.:|..::.||||||..|.:.|..|:.:.:.::
Zfish   470 VERGYRMPCPQGSPASLHELMLQCWRKDPDERHTFEYLQSFLE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	22/95 (23%)
		TyrKc	1063..1311	CDD:197581	107/252 (42%)
		PTKc_Fes_like	1067..1315	CDD:270637	106/252 (42%)
yrk	NP_001352482.1	SH3	76..133	CDD:327375	16/91 (18%)
		SH2	136..234	CDD:326550	24/104 (23%)
		PTKc_Src_Fyn_like	266..513	CDD:271105	106/254 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910