DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and musk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001004503.1	Gene:	musk / 334526	ZFINID:	ZDB-GENE-030131-6458	Length:	941	Species:	Danio rerio

Alignment Length:	368	Identity:	106/368 - (28%)
Similarity:	183/368 - (49%)	Gaps:	61/368 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   993 IVLSVC------WNGHKHFIVQTTGEGNFRFEGPPFASI-QELIMHQYH-----SELPVTVKSGA 1045
            :::.:|      |...|..:::|          |...:: .||::.:.|     ..||:.:.|..
Zfish   582 VLILMCHRRKKMWKKRKSRVLET----------PTLTTLPSELLLDRLHPNPMYQRLPLLLNSKL 636

  Fly  1046 ILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAK---LKSTK--LDVAVKTCRMTLPDEQKRK 1105
            :        ..|...:::..:..||.|.||.|::|:   |..|:  ..||||..:.....:.:..
Zfish   637 L--------SLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPTEPFTMVAVKMLKEEASTDMQND 693

  Fly  1106 FLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK--------------NSNG 1156
            |.:|..::.::||||||:|:|:|...:|:.::.|.:..|.|..:||:              .|:.
Zfish   694 FQREAALMSEFDHPNIVRLLGVCAVGKPMCLMFEYMAYGDLNEFLRRRCATQQPSLSRDTLTSSS 758

  Fly  1157 LTT----------RQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE-- 1209
            |.:          ::|:.:.:..||||.||..:..:|||||.|||||.....|||:|||:||.
Zfish   759 LVSEPERYPPLSCQEQLSISKQVAAGMAYLSERKFVHRDLATRNCLVAENLVVKIADFGLSRNIY 823

  Fly  1210 EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERID 1274
            ..:|..:.....||::|..||::.:.:|||..|||:||:::|||||.|..||.||.:......:.
Zfish   824 AADYYKASENDAIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYYVR 888

  Fly  1275 TGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDAL 1317
            .|..:..|::.|:|:|.||..||:.....||.|..|:.:::.:
Zfish   889 DGNVLSCPENCPQELYNLMRLCWSGHPTDRPSFASIHRILERM 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	9/57 (16%)
		TyrKc	1063..1311	CDD:197581	93/278 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	94/278 (34%)
musk	NP_001004503.1	I-set	26..108	CDD:254352
		Ig	37..108	CDD:299845
		IG_like	124..205	CDD:214653
		Ig	136..198	CDD:299845
		I-set	210..298	CDD:254352
		Ig	212..300	CDD:299845
		CRD_TK_ROR_related	309..449	CDD:143578
		KR	454..536	CDD:214527
		PTKc_Musk	640..930	CDD:133181	95/289 (33%)
		Pkinase_Tyr	646..928	CDD:285015	94/281 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910