DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and src

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_017209008.1	Gene:	src / 325084	ZFINID:	ZDB-GENE-030131-3809	Length:	549	Species:	Danio rerio

Alignment Length:	416	Identity:	142/416 - (34%)
Similarity:	214/416 - (51%)	Gaps:	53/416 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   926 ASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRETI 986
            |..|.:..:||.               |...|:.|:.|.:.|.:..|||    |..|.|||||:
Zfish   145 APSDSIQAEDHL---------------RLTLEKRWYFGKITRRDSERLLLNLENRRGTFLVRES- 193

  Fly   987 RNEESQIVLSVCWNGH------KHFIVQTTGEGNFRFEG-PPFASIQELIMH--QY-----HSEL 1037
            ...:....|||....:      ||:.::....|.|.... ..|:::|:|:.|  |:     ||..
Zfish   194 ETTKGAYCLSVLDYDNVKGLNVKHYKIRKLDSGGFYITSRTQFSTLQQLVNHYRQHADGLCHSLT 258

  Fly  1038 PVTVKSGAILRRP---VCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRM-TL 1098
            .|.    .:|:.|   :.|:.||:..|.:.|..::|:|.||:|:......| ..||:||.:. |:
Zfish   259 DVC----PVLKPPTQGLARDAWEIPRDSLRLDVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTM 318

  Fly  1099 PDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTR--Q 1161
            ..|   .||||.:::|:..|..:|:|..: |.::||.||.|.:..||||.:| |...|...|  |
Zfish   319 SPE---AFLQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMGQGSLLDFL-KGDMGKMLRLPQ 378

  Fly  1162 QMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPV 1224
            .:.|....|:||.|:|..|.:||||.|.|.||......|::|||::|  |:.||....|.| .|:
Zfish   379 LVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAK-FPI 442

  Fly  1225 KWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEM 1289
            |||||||..:|::|...||||:|||:.|:.:||..||.||.|....::::.|||||.|...|:.:
Zfish   443 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPAECPDSL 507

  Fly  1290 YRLMLQCWAADAESRPHFDEIYNVVD 1315
            :.|||.||..:.|.||.|:.:...::
Zfish   508 HELMLTCWRKEPEERPTFEYLQGFLE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	29/103 (28%)
		TyrKc	1063..1311	CDD:197581	102/252 (40%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/252 (40%)
src	XP_017209008.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910