DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and hop

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster

Alignment Length:	404	Identity:	121/404 - (29%)
Similarity:	189/404 - (46%)	Gaps:	88/404 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   965 LPREEVVRLLNNDGDFL-----------VRETI----RNEESQIVLSVCWNGHKHFI-------- 1006
            |.:|:::|..|.||:.|           :.|||    .::|::     .::.|..|.
  Fly   782 LRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETK-----RFSHHDIFSRLNTIKAE 841

  Fly  1007 ----------VQTTGEGN----FRFEGP--PFASIQELIMHQYHSELPVTVKSGAILRRPVCRER 1055
                      :.|.|.|:    .|.:.|  ||.....|::      :|:|.:         ||..
  Fly   842 ILPNYMPPPEIATNGTGDETVIDRSDIPFLPFPRSNMLMV------IPLTSE---------CRVI 891

  Fly  1056 WELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD-----VAVKTCRMTLPDEQKRKFLQEGRILKQ 1115
            :.:.|       .||||::|.|||..|:....|     ||:|   |....:....|.:|..|::.
  Fly   892 YNMEN-------MIGRGHYGTVYKGHLEFNDKDQPREQVAIK---MLNTMQVSTDFHREIGIMRT 946

  Fly  1116 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKN 1180
            ..|||||| .....:|.. .|:||.:..||...|||..:..|...:.:....|.|.||:||....
  Fly   947 LSHPNIVK-FKYWAEKSH-CIIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMG 1009

  Fly  1181 CIHRDLAARNCLVDLEHS-----VKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYT 1238
            .|||||||||.|||  |:     |||||||:::  ..:.|..:...:.||::|.:|||::..:::
  Fly  1010 LIHRDLAARNILVD--HNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIRWYSPEAISTCRFS 1072

  Fly  1239 SLCDVWSYGILMWEIFSKGDTPYSGMTNSRARE---RIDTGYRMPTPKSTPEEMYRLMLQCWAAD 1300
            |..||||||:.::|:||:|:.|......:...:   |:.:|.|:..|.|.|:.:|.||..||.|.
  Fly  1073 SYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWHAT 1137

  Fly  1301 AESRPHFDEIYNVV 1314
            ..|||.|..|.:::
  Fly  1138 PRSRPSFATIVDII 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	21/112 (19%)
		TyrKc	1063..1311	CDD:197581	94/262 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	95/263 (36%)
hop	NP_511119.2	B41	39..259	CDD:214604
		SH2_Jak_family	420..516	CDD:198177
		PTK_Jak_rpt1	584..836	CDD:270633	13/58 (22%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	98/289 (34%)
		TyrKc	894..1151	CDD:197581	96/270 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910