DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Epha4

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001155883.1	Gene:	Epha4 / 316539	RGDID:	1560587	Length:	986	Species:	Rattus norvegicus

Alignment Length:	977	Identity:	240/977 - (24%)
Similarity:	383/977 - (39%)	Gaps:	234/977 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   466 PATPMT----RSRQGRFNKL-QPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHYLGEE 525
            ||..:|    ||.||....: .|.......:|::.:.|  :|.|...:.|  :.:|:..::|..:
  Rat    27 PANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKN--TPIRTYQVCN--VMEASQNNWLRTD 87

  Fly   526 IATSSTNPPDLTRLRRT--QCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHIYADLELDK 588
            ..|..........::.|  .|:.|       |.|:.:            .....|..|.:.:.||
  Rat    88 WITREGAQRVYIEIKFTLRDCNSL-------PGVMGT------------CKETFNLYYYESDNDK 133

  Fly   589 KKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDD----RLKRTLQPSD 649
            ::....|...|.:.|...:...:::|.            |||.:||..:.|    ..|.......
  Rat   134 ERFIRESQFGKIDTIAADESFTQVDIG------------DRIMKLNTEIRDVGPLSKKGFYLAFQ 186

  Fly   650 DVNAIESA-------EENHIQTRKLAKDPDSQTKRSSSSSSECRSS-KDTSHSKKRSLSFSQKS- 705
            ||.|..:.       ::..:..|.||:.||:.|...:||..|.|.| .:.|..|.....:....
  Rat   187 DVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADG 251

  Fly   706 -----ISNIFSNL---KEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHS---SGSDCP------ 753
                 |.|...|.   ::..:....::|....|:.:....:..|  |.:|   ..:.|.
  Rat   252 EWLVPIGNCLCNAGHEEQNGECQACKIGYYKALSTDATCAKCPP--HSYSVWEGATSCTCDRGFF 314

  Fly   754 -----------TNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTI--------------- 792
                       |...|:..|..:|...||.|...|:.|:|.....|:..:
  Rat   315 RADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRP 379

  Fly   793 ---------------TTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKP--- 839
                           ||..:.|....::...|::..:...||...:..:|..:.....::.|
  Rat   380 CGSGVHYTPQQNGLKTTRVSITDLLAHTNYTFEIWAVNGVSKYNPSPDQSVSVTVTTNQAAPSSI 444

  Fly   840 ----CKQCTK-------RRRIHPSKSVFDF-AKEFEVEQPAGS------AADEQFCNCPPAGQKP 886
                .|:.|:       .....|:..:.:: .|.:|.:|...|      ||.    |....|..|
  Rat   445 ALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAAR----NTDIKGLNP 505

  Fly   887 VKPSV------QISGHKD--HPFESSSGELDENSDRDIDNDEEEEDSASDDVL--SMKDHCYCVP 941
            :...|      ..:|:.|  .|.|.::..:   ..|.|.      |.|:..||  |:......|.
  Rat   506 LTSYVFHVRARTAAGYGDFSEPLEVTTNTV---PSRIIG------DGANSTVLLVSVSGSVVLVV 561

  Fly   942 SLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFI 1006
            .|.|:..:|..|..|.:       .::|.                 :||..:...|
  Rat   562 ILIAAFVISRRRSKYSQ-------AKQEA-----------------DEEKHLNQGV--------- 593

  Fly  1007 VQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLER-IG 1070
              .|....|.:|.|..|      :.::..|:..:           |           :.:|: ||
  Rat   594 --RTYVDPFTYEDPNQA------VREFAKEIDAS-----------C-----------IKIEKVIG 628

  Fly  1071 RGNFGDVYKAKLK---STKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQ 1132
            .|.||:|...:||   ..::.||:||.:....|:|:|.||.|..|:.|:|||||:.|.|:..:.:
  Rat   629 VGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCK 693

  Fly  1133 PIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEH 1197
            |:||:.|.:..|||..:||||....|..|.:||.|...:||:||...:.:||||||||.||:...
  Rat   694 PVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNL 758

  Fly  1198 SVKISDFGMSR-----EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKG 1257
            ..|:|||||||     .|..|....|  :||::||||||:.:.|:||..|||||||:|||:.|.|
  Rat   759 VCKVSDFGMSRVLEDDPEAAYTTRGG--KIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYG 821

  Fly  1258 DTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLD 1322
            :.||..|:|....:.|:.|||:|.|...|..:::|||.||..:...||.|.:|.|::|.|| |..
  Rat   822 ERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLI-RNP 885

  Fly  1323 NS 1324
            ||
  Rat   886 NS 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	12/85 (14%)
		TyrKc	1063..1311	CDD:197581	111/256 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	113/256 (44%)
Epha4	NP_001155883.1	EphR_LBD_A4	30..203	CDD:198450	37/207 (18%)
		FN3	329..436	CDD:238020	17/106 (16%)
		FN3	441..532	CDD:238020	18/94 (19%)
		EphA2_TM	562..618	CDD:405290	15/96 (16%)
		PTKc_EphR_A	616..882	CDD:270651	115/289 (40%)
		SAM_EPH-A4	911..981	CDD:188944
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910