DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Csk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001025210.1	Gene:	Csk / 315707	RGDID:	1308800	Length:	450	Species:	Rattus norvegicus

Alignment Length:	366	Identity:	128/366 - (34%)
Similarity:	185/366 - (50%)	Gaps:	32/366 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 WFHGVLPREEVVRLL--NNDGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFRFEGPP 1021
            ||||.:.||:..|||  ...|.|||||: .|......|.|...|. :|:.:..........|...
  Rat    82 WFHGKITREQAERLLYPPETGLFLVRES-TNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVY 145

  Fly  1022 FASIQELIMHQYHSEL---------PVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDV 1077
            |.::.:|:.| |.::.         |..::.....:....|..|.|:..::.||:.||:|.||||
  Rat   146 FENLMQLVEH-YTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDV 209

  Fly  1078 YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICV-QKQPIMIVMELV 1141
            .....:..|  ||||..:   .|...:.||.|..::.|..|.|:|:|:|:.| :|..:.||.|.:
  Rat   210 MLGDYRGNK--VAVKCIK---NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYM 269

  Fly  1142 LGGSLLTYLRKNSNGLTTRQQMGMC-----RDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKI 1201
            ..|||:.|||.....:..    |.|     .|....|.|||..|.:||||||||.||..::..|:
  Rat   270 AKGSLVDYLRSRGRSVLG----GDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKV 330

  Fly  1202 SDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTN 1266
            ||||:::|...   :....::||||||||||...|:::..||||:|||:|||:|.|..||..:..
  Rat   331 SDFGLTKEASS---TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL 392

  Fly  1267 SRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF 1307
            .....|::.||:|..|...|..:|.:|..||..||.:||.|
  Rat   393 KDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTF 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/90 (28%)
		TyrKc	1063..1311	CDD:197581	99/251 (39%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/247 (39%)
Csk	NP_001025210.1	Interaction with PTPN22. /evidence=ECO:0000250\|UniProtKB:P41240	9..70
		SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190	26/94 (28%)
		PTKc_Csk	188..443	CDD:133213	101/258 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910