DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Ephb2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_038965983.1	Gene:	Ephb2 / 313633	RGDID:	1564232	Length:	988	Species:	Rattus norvegicus

Alignment Length:	685	Identity:	186/685 - (27%)
Similarity:	280/685 - (40%)	Gaps:	194/685 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   752 CPTNSSSSSSNNNN---NNKNTSSNSNHSASQSTIITSTITTTITTTTTT------TPSKENSRL 807
            ||.||.::|....|   .|....::.:......|.|.|.....|::...|      ||.:::.
  Rat   289 CPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSG-- 351

  Fly   808 KFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRR----------------------RIH 850
                    .:...:.|..              ||.|...|                      ||:
  Rat   352 --------GREDLVYNII--------------CKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIY 394

  Fly   851 PSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKP---SVQISGHKDHPFESSSGELDENS 912
            .|..:......||: |......|          |.|..|   ||.|:.::..|   |:..:....
  Rat   395 ISDLLAHTQYTFEI-QAVNGVTD----------QSPFSPQFASVNITTNQAAP---SAVSIMHQV 445

  Fly   913 DRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNND 977
            .|.:|                            ||:||.::|    :..:||        :|:.:
  Rat   446 SRTVD----------------------------SITLSWSQP----DQPNGV--------ILDYE 470

  Fly   978 GDFLVRETIRNEESQIVLS----VCWNGHKH---FIVQT---TGEGNFRFEGPPFASIQELIMHQ 1032
            ..:..::.:....:..:.|    |...|.|.   ::.|.   |..|..|:.|..:  .|.:...:
  Rat   471 LQYYEKQELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMY--FQTMTEAE 533

  Fly  1033 YHS----ELPVTVKSGA---------ILRRPVCRER----------------------------- 1055
            |.:    :||:.|.|.|         ::...||..|
  Rat   534 YQTSIKEKLPLIVGSSAAGVVFVIAVVVIAIVCNRRRGFERADSEYTDKLQHYTSGHMTPGMKIY 598

  Fly  1056 -----WELSNDDV-----------VLLER-IGRGNFGDVYKAKLK---STKLDVAVKTCRMTLPD 1100
                 :|..|:.|           |.:|: ||.|.||:|....||   ..::.||:||.:....:
  Rat   599 IDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTE 663

  Fly  1101 EQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGM 1165
            :|:|.||.|..|:.|:||||::.|.|:..:..|:||:.|.:..|||.::||:|....|..|.:||
  Rat   664 KQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGM 728

  Fly  1166 CRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE------YIVSDGMKQIPV 1224
            .|..||||:||...|.:||||||||.||:.....|:||||:||..|:      |..:.|.| ||:
  Rat   729 LRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGK-IPI 792

  Fly  1225 KWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEM 1289
            :||||||:.:.|:||..|||||||:|||:.|.|:.||..|||......|:..||:|.|...|..:
  Rat   793 RWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSAL 857

  Fly  1290 YRLMLQCWAADAESRPHFDEIYNVVDALILRLDNS 1324
            ::|||.||..|...||.|.:|.|.:|.:| |..||
  Rat   858 HQLMLDCWQKDRNHRPKFGQIVNTLDKMI-RNPNS 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	16/99 (16%)
		TyrKc	1063..1311	CDD:197581	114/268 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	114/257 (44%)
Ephb2	XP_038965983.1	EphR_LBD_B2	19..196	CDD:198445
		fn3	326..421	CDD:394996	19/129 (15%)
		fn3	437..521	CDD:394996	19/123 (15%)
		EphA2_TM	<566..619	CDD:405290	5/52 (10%)
		PTKc_EphR_B	618..886	CDD:173638	116/268 (43%)
		SAM_EPH-B2	912..982	CDD:188951
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910