DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Ripk1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001100820.1	Gene:	Ripk1 / 306886	RGDID:	1310158	Length:	658	Species:	Rattus norvegicus

Alignment Length:	280	Identity:	79/280 - (28%)
Similarity:	133/280 - (47%)	Gaps:	41/280 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 ELSNDDVVLLER--IGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPD--EQKRKFLQEGRILKQYD 1117
            ::::||  ||||  :..|.||.|.....::....:..|.  .|.|:  |.....|:||:::.:..
  Rat    11 KMASDD--LLERKDLDSGGFGKVSLCFHRTHGFVILKKV--YTGPNRAEYNEALLEEGKMMHRLR 71

  Fly  1118 HPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR-KNSNGLTTRQQMGMCRDAAAGMRYLESKNC 1181
            |..:|||:||.:::....:|||.:..|:|:..|: |.|..|:.:.::.:  :...||.||..:..
  Rat    72 HDRVVKLLGIIIEEGNYSLVMEYMEQGNLMHVLKTKESVPLSVKGRIIV--EIIEGMHYLHDEGV 134

  Fly  1182 IHRDLAARNCLVDLEHSVKISDFGMSR-------EEEEYIVSDGMKQIPVK------WTAPEALN 1233
            ||:||...|.|||.:..:||:|.|::.       .:||:........:..|      :.|||.|.
  Rat   135 IHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEEHNKQREASSVTKKNGGTLYYMAPEHLT 199

  Fly  1234 --FGKYTSLCDVWSYGILMWEIFSKGDTPYSGM---------TNSRARERIDTGYRMPTPKSTPE 1287
              ..|.|...||:|:.|::|.||:..: ||..:         .||..|..::     ...:..|.
  Rat   200 DINTKPTEKSDVYSFAIVLWAIFANKE-PYENVICTEQFLVCINSGNRPNVE-----DILEFCPR 258

  Fly  1288 EMYRLMLQCWAADAESRPHF 1307
            |:..||.:||..:.|.||.|
  Rat   259 EIISLMERCWQTNPEDRPTF 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	77/274 (28%)
		PTKc_Fes_like	1067..1315	CDD:270637	75/270 (28%)
Ripk1	NP_001100820.1	PKc_like	23..290	CDD:419665	73/266 (27%)
Ripk1	NP_001100820.1	Death_RIP1	570..655	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900