DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and ephb4a

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_571489.1	Gene:	ephb4a / 30688	ZFINID:	ZDB-GENE-990415-62	Length:	987	Species:	Danio rerio

Alignment Length:	1062	Identity:	243/1062 - (22%)
Similarity:	384/1062 - (36%)	Gaps:	322/1062 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 ISNGSNTSNGIQS-------NKDSLCRQSKDLNALRCQEKQKQKLVDMIKCALNEV---GCEE-- 400
            :|.....:|.:::       ...|.|.:||.:......:...:....|::|:....   .|:|
Zfish    54 VSGLDEENNSVRTYQICQADGSSSHCVRSKLIERRGASQVYVELFFTMVECSSRNTHHRSCKETF 118

  Fly   401 ----LPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGG-----VLTLLRGRGR 456
                ..|..||.......::||.|.    :.::.::      :.|:|:||     |.||..|
Zfish   119 NLYYYQSDTDDATATHPAWMENPYT----KVDTVAA------DFLLRKGGEKKVNVKTLRLG--- 170

  Fly   457 HFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSV-IRDGNGPSPARYEPITNHRLRQAASVH 520
                        |:  |::|.:...|.:...:..||| :.....|:..|...:....:.::....
Zfish   171 ------------PL--SKRGFYLAFQAQGACMALLSVRVFFKKCPALTRSLSVFPETVPRSLVQE 221

  Fly   521 YLGEEIATS-----STNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHI 580
            .:|:.:|.:     |..||          .|.| |||.:.|    ..|.|  |...|.....:|
Zfish   222 AVGQCVANAAQPGPSPRPP----------KMFC-GEDGQWV----DQPTT--TCTCLPGFEASH- 268

  Fly   581 YADLE--------LDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVL 637
             .:||        ......|.|...|.             |.:||....|. |.:.| ....|.|
Zfish   269 -GELECRACPVGLFKMGSGTGPCSVCP-------------ENSQTGETGSA-ACVCR-SGFYRAL 317

  Fly   638 DDRLKR--TLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLS 700
            .|....  |..||...:.:....:..: |.:.::..||..:...|.|.|||......
Zfish   318 SDSADTPCTRPPSSPRSPVPQVNDTSL-TLEWSEPLDSGGRSDLSYSVECRMCSTPG-------- 373

  Fly   701 FSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQ---------------HHHSSGS 750
                            |...|...|.|:           :|||               |...|.:
Zfish   374 ----------------SPCTLCSDGVNY-----------RPSQTGIQGRRVSIWGLRPHTTYSFT 411

  Fly   751 DCPTNSSSSSSNNN--NNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPK 813
            ....|..|:.|...  ....|.:::.|.....|.:..||.|.:..|....||::.:.|
Zfish   412 VMALNGVSAQSQQGPAGETINITTSPNVPVLVSGLRKSTATESSLTLYWNTPTQSHYR------- 469

  Fly   814 IQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCN 878
                           :|.:|:      :.|.|.|                       .::|..|
Zfish   470 ---------------ILQYQI------RYCEKER-----------------------GSEENSC- 489

  Fly   879 CPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDE----------------------- 920
                                |..||::.|:..:..|.....|
Zfish   490 --------------------HYMESNNNEVVLSDLRRATQYEVQVRARTFAGYGSFGKAILFRTL 534

  Fly   921 -EEEDSAS----DDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDF 980
             :|:||:|    ..:|........:..:.|:|.....:..|::.            .|.:.:|.:
Zfish   535 PDEDDSSSPLLVTGILIAMGMLLLIIVIGAAIYCIRKQNNYKDP------------ELSDKNGQY 587

  Fly   981 LVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGA 1045
            |:.:                |.|.:|      ..|.:|.|..|      :.::..|:.|:
Zfish   588 LMGQ----------------GVKVYI------DPFTYEDPNEA------VREFAKEIDVS----- 619

  Fly  1046 ILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLK---STKLDVAVKTCRMTLPDEQKRKFL 1107
                  |          |.:.|.||.|.||:|.:.:|:   ..:..||:||.:....|:|:|.||
Zfish   620 ------C----------VKIEEVIGAGEFGEVCRGRLRIPGKKENYVAIKTLKGGYTDKQRRDFL 668

  Fly  1108 QEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAG 1172
            .|..|:.|:.||||:.|.||.....|:||:.|.:..|:|.::||.|....|..|.:||.|..|:|
Zfish   669 AEASIMGQFQHPNIIHLEGIITASCPVMILTEFMENGALDSFLRLNDGQFTPIQLVGMLRGIASG 733

  Fly  1173 MRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE------YIVSDGMKQIPVKWTAPEA 1231
            |:||...:.:||||||||.||:.....|:||||:||..:|      |..|.|.| ||::||||||
Zfish   734 MKYLSEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLQENSSDPTYTSSLGGK-IPIRWTAPEA 797

  Fly  1232 LNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQC 1296
            :.|.|:|...|||||||:|||:.|.|:.||..|:|......|:..||:|.|......:::|||.|
Zfish   798 IAFRKFTCASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCSTYLHQLMLDC 862

  Fly  1297 WAADAESRPHFDEIYNVVDALI 1318
            |..:..:||.|..|.:.:|.||
Zfish   863 WQKERTARPRFANIVSALDKLI 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	12/85 (14%)
		TyrKc	1063..1311	CDD:197581	109/256 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	109/256 (43%)
ephb4a	NP_571489.1	EphR_LBD	26..199	CDD:383093	31/171 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..340		4/20 (20%)
		FN3	339..435	CDD:238020	21/131 (16%)
		FN3	440..533	CDD:238020	21/164 (13%)
		EphA2_TM	551..616	CDD:373140	13/104 (13%)
		PTKc_EphR_B	616..884	CDD:173638	113/289 (39%)
		SAM_EPH-B4	914..980	CDD:188953
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910