DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and HCK

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_002101.2	Gene:	HCK / 3055	HGNCID:	4840	Length:	526	Species:	Homo sapiens

Alignment Length:	490	Identity:	162/490 - (33%)
Similarity:	249/490 - (50%)	Gaps:	76/490 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   878 NCP-------------PAGQKPVKPSVQISGHKD------HPFESSSGELD---ENSDRDIDNDE 920
            :||             |.......|.::.:|.:|      :.:|:...| |   :..|:.:..:|
Human    47 HCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHE-DLSFQKGDQMVVLEE 110

  Fly   921 EEEDSASDDVLSMKDHCYCVPS--LAASISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGD 979
            ..|...:..:.:.|:.  .:||  :|...||.|      ||||...:.|::..|.|    |..|.
Human   111 SGEWWKARSLATRKEG--YIPSNYVARVDSLET------EEWFFKGISRKDAERQLLAPGNMLGS 167

  Fly   980 FLVR--ETIRNEESQIVLSV------CWNGHKHFIVQTTGEGNFRFEGP--PFASIQELIMHQYH 1034
            |::|  ||.:...|   |||      ..:..||:.::|...|.| :..|  .|:::|||:.|...
Human   168 FMIRDSETTKGSYS---LSVRDYDPRQGDTVKHYKIRTLDNGGF-YISPRSTFSTLQELVDHYKK 228

  Fly  1035 ------SELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKL-KSTKLDVAVK 1092
                  .:|.|...|.. .::|..::.||:..:.:.|.:::|.|.||:|:.|.. |.||  ||||
Human   229 GNDGLCQKLSVPCMSSK-PQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTK--VAVK 290

  Fly  1093 TCRMTLPDEQK-RKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG 1156
            |.:   |.... ..||.|..::|...|..:|||..: |.|:||.|:.|.:..||||.:|:.:..
Human   291 TMK---PGSMSVEAFLAEANVMKTLQHDKLVKLHAV-VTKEPIYIITEFMAKGSLLDFLKSDEG- 350

  Fly  1157 LTTRQQMGMCRDAAA----GMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIV 1215
              ::|.:....|.:|    ||.::|.:|.|||||.|.|.||......||:|||::|  |:.||..
Human   351 --SKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTA 413

  Fly  1216 SDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMP 1280
            .:|.| .|:|||||||:|||.:|...||||:|||:.||.:.|..||.||:|......::.|||||
Human   414 REGAK-FPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMP 477

  Fly  1281 TPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVD 1315
            .|::.|||:|.:|::||....|.||.|:.|.:|:|
Human   478 RPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	29/105 (28%)
		TyrKc	1063..1311	CDD:197581	106/255 (42%)
		PTKc_Fes_like	1067..1315	CDD:270637	107/255 (42%)
HCK	NP_002101.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SH3	82..137	CDD:302595	10/57 (18%)
		SH2_Src_HCK	140..243	CDD:198226	31/112 (28%)
		PKc_like	254..524	CDD:304357	111/269 (41%)
		Pkinase_Tyr	262..511	CDD:285015	107/258 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910