DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and ret

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_858048.2	Gene:	ret / 30512	ZFINID:	ZDB-GENE-980526-307	Length:	1106	Species:	Danio rerio

Alignment Length:	1050	Identity:	231/1050 - (22%)
Similarity:	370/1050 - (35%)	Gaps:	298/1050 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 RSNSTSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGS 490
            ||.|..||     .:|..:.||             .|||......|         :.|..:.  .
Zfish    97 RSGSVRSP-----KDLTLKVGV-------------SSTPPMKVMCT---------ILPTVEV--K 132

  Fly   491 LSVIRDGNGPSPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEP 555
            ||.|.| ..||..:.|..|.....:.::.|      .|.:..|..|.:|||.....:|      |
Zfish   133 LSFIND-TAPSCGQVELSTLCFPEKISNPH------ITENREPGALRQLRRFTHMSIC------P 184

  Fly   556 -------VVLASPAPLT------------------------QLTAAVLTNTNNNHIYADLELDKK 589
                   ||..|..|..                        .:...|.|..|...::..|.::..
Zfish   185 NYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKEVYHLDIVCMVRTERNLEEVFRSLHVNIY 249

  Fly   590 KDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHL---DR----IDELNRVLDDRLKRTLQP 647
            .:...||...|..    .|.:.:|.:::  :.::...|   ||    :...|:| .::|..||..
Zfish   250 DEDDNSPYVNGTD----TEDVLVEFDRS--EGTVFGTLFVYDRDTTPVYPTNQV-QNKLVGTLMT 307

  Fly   648 SDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFSN 712
            :|.......|.|:..:..|..    ....|.:....:.:.|::.|.:::||...........|..
Zfish   308 NDSWIKNNFAIEHKFREEKAI----FGNVRGTVHEYKLKLSQNLSVTEQRSFLLGYLVNDTTFPG 368

  Fly   713 -----LKEFSKSPL---VRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSS----------- 758
                 |..|:.:.|   :|..     |.......:|.:..:...|..|..|...
Zfish   369 PEGTVLLHFNVTVLPVPIRFS-----NVTYSFTVSQKATTYSQIGKVCVENCQKFKGIDVTYQLE 428

  Fly   759 ---------------SSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLK 808
                           :.|...|.|.||.                  ......|......|...|:
Zfish   429 IVDRNITAEAQSCYWAVSLAQNPNDNTG------------------VLYVNDTKVLRRPECQELE 475

  Fly   809 FKVPKIQKKSKAIRNTFRSKLLNFQ-----LKRSKP----CKQCTKRRRIHPSKSVFDFAKEFEV 864
            :.|...::::|....|  ...::||     ||..:|    |.:..:|.....::.:.......:.
Zfish   476 YVVIAQEQQNKLQAKT--QLTVSFQGEADSLKTDEPRFPACAEKRQRGDCEATRGLGAPTGRCQW 538

  Fly   865 EQPAGSAADEQFCNCPP-AGQKPVKPSVQISGHKDH---------PFESSSGELDENSDRDI--- 916
            .|.......:::..|.| .|..|       .|:.|.         |.:.||..:....:||:
Zfish   539 RQGRDKGISKRYSTCSPNLGTCP-------DGYCDAIESKNISICPQDCSSEAIIGGYERDLYGI 596

  Fly   917 ----------------DNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVL 965
                            :.||.|:|..:|         .|...:|..|.||
Zfish   597 KAGHGTCYCFEGKCFCERDEPEDDICND---------MCKTVIATGIILS--------------- 637

  Fly   966 PREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIM 1030
                          |:|         .::||..:....|   :||.:       ||.|| .|:..
Zfish   638 --------------FIV---------SVLLSSYFIHRYH---KTTPK-------PPIAS-AEMTF 668

  Fly  1031 HQYHSELPVTVKSGAILRRPVCR---------------ERWELSNDDVVLLERIGRGNFGDVYKA 1080
            .:.....|::..:..:.|..:..               .:||....::||.:.:|.|.||.|.||
Zfish   669 RRPAQSYPISYSANNVRRASLDSMENQVAIDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKA 733

  Fly  1081 -----KLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMEL 1140
                 |.|:....||||..:......:.|..|.|..:|||.:||:::|:.|.|.|..|:.:::|.
Zfish   734 TAFRLKGKAGYTTVAVKMLKENASHSELRDLLSEFTLLKQVNHPHVIKMYGACSQDGPLYLIVEY 798

  Fly  1141 VLGGSLLTYLR---------------KNSN--------GLTTRQQMGMCRDAAAGMRYLESKNCI 1182
            ...|||..:||               :||:        .||....:......:.||:||.....:
Zfish   799 AKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENPDERALTMGDLISFAWQISRGMQYLAEMKLV 863

  Fly  1183 HRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWS 1245
            ||||||||.||.....:||||||:||:  ||:..|.....:|||||.|.|:|....||:..||||
Zfish   864 HRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWS 928

  Fly  1246 YGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            :|:|:|||.:.|..||.|:...|....:.|||||..|::..:|||.|||:||..:::.||.|.:|
Zfish   929 FGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCTDEMYNLMLRCWKQESDKRPTFSDI 993

  Fly  1311 YNVVDALILR 1320
            ...::.::::
Zfish   994 SKELEKMMVK 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	12/85 (14%)
		TyrKc	1063..1311	CDD:197581	104/277 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/277 (37%)
ret	NP_858048.2	CA	186..256	CDD:214520	8/69 (12%)
		PTKc_RET	715..1004	CDD:173631	105/288 (36%)
		Pkinase_Tyr	716..997	CDD:285015	105/280 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910