DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Abl2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_038946666.1	Gene:	Abl2 / 304883	RGDID:	1590898	Length:	1188	Species:	Rattus norvegicus

Alignment Length:	386	Identity:	136/386 - (35%)
Similarity:	210/386 - (54%)	Gaps:	34/386 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 LYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFR 1016
            |.:..|:||.:.|.....||::  :|.|||||: .:...|:.:|:.:.|. .|:.:.||.:....
  Rat   168 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRES-ESSPGQLSISLRYEGRVYHYRINTTTDSKVY 231

  Fly  1017 FEGPP-FASIQELIMHQYHSELPVTVKSGAILR----RPVC-----------RERWELSNDDVVL 1065
            ..... |:::.||:.|  ||    ||..|.:..    .|.|           .::||:...|:.:
  Rat   232 VTAESRFSTLAELVHH--HS----TVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITM 290

  Fly  1066 LERIGRGNFGDVYKAKLKSTKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICV 1129
            ..::|.|.:|:||....|...|.|||||.:. |:..|:   ||:|..::|:..|||:|:|:|:|.
  Rat   291 KHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEE---FLKEAAVMKEIKHPNLVQLLGVCT 352

  Fly  1130 QKQPIMIVMELVLGGSLLTYLRKNS-NGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLV 1193
            .:.|..||.|.:..|:||.|||:.| ..:|....:.|....::.|.|||.||.||||||||||||
  Rat   353 LEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV 417

  Fly  1194 DLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSK 1256
            ...|.||::|||:||  ..:.|....|.| .|:||||||:|.:..::...|||::|:|:|||.:.
  Rat   418 GENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATY 481

  Fly  1257 GDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDAL 1317
            |.:||.|:..|:..:.::.||||..|:..|.::|.||..||......||.|.|.:...:.:
  Rat   482 GMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETM 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/87 (29%)
		TyrKc	1063..1311	CDD:197581	103/251 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/251 (41%)
Abl2	XP_038946666.1	SH3_Abl	111..164	CDD:212784
		SH2_ABL	169..262	CDD:198189	27/99 (27%)
		PTKc_Abl	281..543	CDD:270645	106/266 (40%)
		FABD	1069..1188	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810