DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and jak2b

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_571162.1	Gene:	jak2b / 30298	ZFINID:	ZDB-GENE-980526-123	Length:	1126	Species:	Danio rerio

Alignment Length:	415	Identity:	118/415 - (28%)
Similarity:	182/415 - (43%)	Gaps:	82/415 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   945 ASISLSTNRPLYEEEWFHGVLPR---EEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFI 1006
            |::..|.....||.   |..||.   .|:..|:|:..|:
Zfish   740 ANMDNSKKHLFYEN---HHQLPAPKWTELANLINSCMDY-------------------------- 775

  Fly  1007 VQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVC----------RERWELSND 1061
                 |..||   |.|.:|...:...:..:..:..:|..:..|...          .|..:....
Zfish   776 -----EPTFR---PSFKAIIRDLNSLFCPDYEIVKESDIMPSRAAASIFNTGTFKNNEPVQFEER 832

  Fly  1062 DVVLLERIGRGNFGDV----YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIV 1122
            .::.|:::|:||||.|    |.....:|...||||..:.: ..|..|.|.:|..|||...|.|||
Zfish   833 HLIFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS-TTEHIRDFEREIEILKSLQHENIV 896

  Fly  1123 KLIGIC--VQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRD 1185
            |..|:|  ..::.:.:|||.:..|||..||.||.:.:..::.:........||.||.:|..||||
Zfish   897 KYKGVCYGAGRRNLRLVMEYLPYGSLRDYLNKNRDRIDHQKLVHYASQICKGMEYLATKRYIHRD 961

  Fly  1186 LAARNCLVDLEHSVKISDFGMSR---EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYG 1247
            ||.||.||:.|..|||.|||:::   :::||.......:.|:.|.|||:|...|::...||||:|
Zfish   962 LATRNILVESECRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWHAPESLTESKFSVASDVWSFG 1026

  Fly  1248 ILMWEIFSKGD------TPYSGMTNSRAR---------ERIDTGYRMPTPKSTPEEMYRLMLQCW 1297
            ::::|:|:..|      |.:..|.....:         |.:..|.|:|.|...|.||:.:|.:||
Zfish  1027 VVLYELFTYSDKLCSPPTVFLSMVGGDKQGQTIVYHLIELLKRGNRLPQPMGCPTEMFEIMQECW 1091

  Fly  1298 AADAESRPHFDEIYNVVDALILRLD 1322
            ..|...||:|.|       |.||:|
Zfish  1092 DNDPSLRPNFKE-------LALRVD 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/88 (17%)
		TyrKc	1063..1311	CDD:197581	94/271 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	93/271 (34%)
jak2b	NP_571162.1	B41	29..262	CDD:214604
		FERM_B-lobe	144..253	CDD:271216
		FERM_C_JAK2	258..370	CDD:270141
		SH2_Jak2	370..466	CDD:198242
		PKc_like	528..791	CDD:304357	17/87 (20%)
		Pkinase_Tyr	528..790	CDD:285015	17/86 (20%)
		PKc_like	829..1112	CDD:304357	98/289 (34%)
		TyrKc	834..1104	CDD:197581	94/277 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810