DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and jak1

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_571148.1 Gene:jak1 / 30280 ZFINID:ZDB-GENE-980526-142 Length:1153 Species:Danio rerio


Alignment Length:1412 Identity:296/1412 - (20%)
Similarity:498/1412 - (35%) Gaps:396/1412 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 ELRLMETMKRSIQMKAKCDKEYAISLTAVAQQGLKIDRADEMQGSLISKSWRSYMDELDHQAKQF 87
            ||.:|: :.|.:.:|.|..::..::: ..|.:||:|               ..|:.: .||.:.|
Zfish     3 ELAVMD-LGRQLCVKMKKQRKAEMTI-PTAMKGLEI---------------HFYLAD-THQLEFF 49

  Fly    88 K--FNAEQLEV----------VCDKLTHL---SQD----KRKARKAYQEEHAKIAARLN------ 127
            |  :.||.|.|          :|..|..|   |||    .....|...|...|:..|:.      
Zfish    50 KACYTAEDLCVEAAKRCRISPLCHNLFALYEESQDLWYAPNHVFKVTDETSIKLHYRMRFYFTNW 114

  Fly   128 HLTDEV---------VRKKS--EYQKHLEGYKALRTRFEENYIKAPSRSG--RKLDDVRDKYQKA 179
            |.|.|:         .::||  ..||..||...|... ..:|:.|..:..  |.|..||.     
Zfish   115 HGTSEIESPVWRHTLSKQKSVLNSQKTTEGTPLLDAA-SLDYLFAQGQYDFLRGLSPVRP----- 173

  Fly   180 CRKLHLTHNEYVLSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADK 244
                  |.|:     .|..|:|.:...:.:..:..|.:|         .|:....|  |..|:  
Zfish   174 ------TQND-----EEHREIENECLGMAVLAITHHAKS---------NNLPLSGA--GAETS-- 214

  Fly   245 YKEIQKRIDTVIGSINPTEEYGEFTEKYKTSPT-TPLLFQFDETLIQDIPGKLQSSTLTVDNLTV 308
            ||..      :..|:|.|.:...|..:.:.|.. ...|.:|:...|||       |.:.:.:|.|
Zfish   215 YKRF------IPDSLNRTIKQRNFLTRIRISNVFKNFLNEFNSKTIQD-------SNIGLYDLKV 266

  Fly   309 DWLRNRLQELEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLN 373
            .:|.......:|..|:..:.:...:...:.|||.....:..||......:........|:....|
Zfish   267 KYLSTLETLTQGVGREIFKPKNLKVTGESEGSPAQMLPLGDNGMGYEVQVYGTTGISWRRKPAPN 331

  Fly   374 ALRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIM 438
            .|..::|.|.|.:                .|            :..:|::::.|..|.......:
Zfish   332 QLILKDKPKSKKI----------------KG------------DKQWNDKKKDSGWTLFSDFHEI 368

  Fly   439 NELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNK-----LQPRSQSLGSLSVIRDGN 498
            ..::.:...:|:.|                        :.||     |..|..:| |.:.:.|| 
Zfish   369 THIVIKDCCVTIYR------------------------QDNKTMELDLFYRDAAL-SFAALVDG- 407

  Fly   499 GPSPARYEPITNHRLRQAASVHYLGEEIATSST--------NPPDLT-----RLRRTQCSMLCLG 550
                  |..:|      ..:.|||..::|.||.        :.|..|     :||:.       |
Zfish   408 ------YFRLT------VDAHHYLCTDVAPSSVVQNLENGCHGPICTEYAIHKLRQE-------G 453

  Fly   551 EDEEPVVLASPAPLTQLTAAVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEIN 615
            .:|...||....  |:....::|       ...:||| ..::.|.|:.|..||            
Zfish   454 NEEGTYVLRWSC--TEYNFIIMT-------VVCIELD-LCESRPVPQYKNFQI------------ 496

  Fly   616 QTAPQN----SIDAHLDRIDELNRVLDDRLKRT------------LQPSDDVNAIESAEENHIQT 664
            :|:||.    ..|.....:.||...|..:|.||            .||.:..|.:....:     
Zfish   497 ETSPQGYRLYGTDTFRPTLKELLEHLQGQLLRTDNLRFQLRRCCPPQPREISNLLVMTTD----- 556

  Fly   665 RKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHI 729
                ::|..|.|...|                 .|||.                    |:.|..|
Zfish   557 ----REPVPQKKTQVS-----------------QLSFD--------------------RILKEEI 580

  Fly   730 LNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNN----KNTSSNSNHSASQSTIITSTITT 790
            :..|...:.|:.:.:   :|...|.:.........:..    .....:.:...|.:...|:::..
Zfish   581 VQGEHLGRGTRTNIY---AGILKPKSDDEDDLGGYSQEVKVVLKVLGSGHRDISLAFFETASMMR 642

  Fly   791 TITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSV 855
            .|        |.::..|.:.|....:::..:....:...|:..:           ||:..|..: 
Zfish   643 QI--------SHKHIALLYGVCVRHQENIMVEEFVQYGPLDLFM-----------RRQTTPLST- 687

  Fly   856 FDFAKEFEVEQPAGSA----ADEQFCN---CPPAGQKPVKPSVQISGHKDHPFESSSGELDENSD 913
               |.:|:|.:...||    .|::..:   |          |..|...:| ..:...|...:.||
Zfish   688 ---AWKFQVAKQLASALSYLEDKKMVHGYVC----------SKNILVARD-GLDGEGGPFIKLSD 738

  Fly   914 RDIDNDEEEEDSASDDVLSMKDHCYCVPSLAAS-ISLSTNRPLYEEEWFHGVLPREEVVRLLNND 977
            ..|          ...|||.::....:|.:|.. :..:.|..:..::|..|....|     :..:
Zfish   739 PGI----------PITVLSREECVDRIPWIAPECVKDTANLSIAADKWSFGTTLWE-----ICYN 788

  Fly   978 GDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVK 1042
            |:..:::....|:.:...:.|                 :...|....:.:|:.|....:....:.
Zfish   789 GEIPLKDKKLTEKERFYAAQC-----------------QLATPDCDELAKLMTHCMTYDPRQRLF 836

  Fly  1043 SGAILRRPVCRERWELSNDDVVLLE---------------RIGRGNFGDV----YKAKLKSTKLD 1088
            ..||:|..|..|:...|...|.:||               .:|.|:||.|    |..:...|...
Zfish   837 FRAIVRDIVMVEKQNPSIQPVPMLEVDPTVFEKRFLKKIRDLGEGHFGKVELCRYDPRGDRTGEL 901

  Fly  1089 VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQK--QPIMIVMELVLGGSLLTYLR 1151
            ||||:.:....:||.....:|..||::..|.||||..|||.::  :.|.::||.:..|||..||.
Zfish   902 VAVKSLKPENREEQSNNLWREIHILRELYHENIVKYKGICNEEGGRSIKLIMEFLPAGSLKEYLP 966

  Fly  1152 KNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR----EEEE 1212
            :|...:..:..:........||.||.|:|.|||||||||.||:.|.:|||.|||:::    .|..
Zfish   967 RNKAHINLKTLLNYSVQICQGMDYLGSRNYIHRDLAARNVLVENEGTVKIGDFGLTKSIKDNEGY 1031

  Fly  1213 YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDT-------------PYSG- 1263
            |.|.|.:.. ||.|.|||.|...|:....||||:|:.|:|:.:..|.             |..| 
Zfish  1032 YTVKDDLDS-PVFWYAPECLIHCKFYRASDVWSFGVTMYELLTYCDASCSPMSVFLKLIGPTHGQ 1095

  Fly  1264 MTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            ||.:|..:.::.|.|:|.|....|::|.||.:||.|..|.|.:|..:
Zfish  1096 MTVTRLVKVLEEGKRLPRPDDCSEQLYNLMRRCWEATPEKRINFKSL 1142

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341 56/257 (22%)
SH2_Fps_family 953..1039 CDD:198224 9/85 (11%)
TyrKc 1063..1311 CDD:197581 99/287 (34%)
PTKc_Fes_like 1067..1315 CDD:270637 97/283 (34%)
jak1NP_571148.1 B41 35..276 CDD:214604 63/299 (21%)
FERM_C_JAK1 280..422 CDD:275412 31/207 (15%)
SH2_Jak1 422..523 CDD:198241 27/129 (21%)
PTK_Jak1_rpt1 580..845 CDD:270662 47/333 (14%)
Pkinase_Tyr 580..844 CDD:285015 47/332 (14%)
PKc_like 867..1150 CDD:304357 96/277 (35%)
Pkinase_Tyr 872..1146 CDD:285015 96/272 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100013
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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