DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Pik3r2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_038950364.1	Gene:	Pik3r2 / 29741	RGDID:	68341	Length:	741	Species:	Rattus norvegicus

Alignment Length:	732	Identity:	125/732 - (17%)
Similarity:	227/732 - (31%)	Gaps:	246/732 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 LGSLSVIRDG---NGPSPARYEPI-----TNHRLRQAASVHYLGEEIATSSTNPPDLTRL----R 540
            ||.:::.|.|   .||.|....|:     :.|.|..      |.|:.:.....||.|.:|    .
  Rat    78 LGPVALARPGPRPRGPRPLPARPLDGPSESGHTLAS------LAEQFSPPEPAPPILVKLIEAIE 136

  Fly   541 RTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHIYADLELDKKKD-------TSPSPEC 598
            :.:....|....|      .|||.|..:.:.|...:...:|     |..|.       ...:||.
  Rat   137 QAELDSECYSRPE------LPAPRTDWSLSDLEQWDRTTLY-----DAVKGFLLALPAAVVTPEA 190

  Fly   599 KGEQIQPKKEQI----------RIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNA 653
            ..|..:..:|..          .:.::|......:..||.|:          .:|...|:..|:|
  Rat   191 ASEAYRAMREVTGPVGLVLEPPTLPLHQALTLQFLLQHLGRV----------ARRAPSPATAVHA 245

  Fly   654 IESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSK 718
            :.||    .....|...|.........:...|.|...|.....||            ....:|..
  Rat   246 LASA----FGPLLLRAPPPGGEGDGPHTWRSCHSQALTPLLAPRS------------EPAPDFPV 294

  Fly   719 SPLVRMGKNHILNEEQDA---------KRTQPSQHHHSSGSDCPT-------------------- 754
            ..|.|:.:.|:  :|||.         .:.:|:....::|...|:
  Rat   295 LLLERLVQEHV--DEQDTAPPALPPKPSKVKPAPTALANGGSTPSLQDAEWYWGDISREEVNERL 357

  Fly   755 -----------NSSSS-------SSNNNNNNK--NTSSNSNHSASQSTIITSTITTTIT----TT 795
                       ::||.       :.....|||  .......|......:...::...|:    .:
  Rat   358 RDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVELISHYRHES 422

  Fly   796 TTTTPSKENSRLKFKVPKIQK--------------KSKAIRNTFRSKLLNF-------------- 832
            .....:|.::||.:.|.|.|:              :.|.....::.|...:
  Rat   423 LAQYNAKLDTRLLYPVSKYQQDQVVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQEL 487

  Fly   833 QLKRS----------------KPCKQCTK------RR----------------------RIHPSK 853
            |:||:                :..::|:|      ||                      .||.|:
  Rat   488 QMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESR 552

  Fly   854 SVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPS-VQISGHKDHPF----ESSSGELDENSD 913
            :..:  ::...:.......|::        ...:||. :|:...:|...    :..:.:...|..
  Rat   553 TKLE--QDLRAQASDNREIDKR--------MNSLKPDLMQLRKIRDQYLVWLTQKGARQRKINEW 607

  Fly   914 RDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLN--N 976
            ..|.|:.|::.|..:|..::..|                   .|..|:.|.:.|.:...:|:  .
  Rat   608 LGIKNETEDQYSLMEDEDALPHH-------------------EERTWYVGKINRTQAEEMLSGKR 653

  Fly   977 DGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFRFEGP--PFASIQELIMHQYHSEL- 1037
            ||.||:||:  ::......||..:|. ||.::..|..| |.|..|  .:.|::||::|..|:.|
  Rat   654 DGTFLIRES--SQRGCYACSVVVDGDTKHCVIYRTATG-FGFAEPYNLYGSLKELVLHYQHASLV 715

  Fly  1038 ----PVTVKSGAILRRP 1050
                .:||.....:|.|
  Rat   716 QHNDALTVTLAHPVRAP 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/95 (28%)
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
Pik3r2	XP_038950364.1	SH3_PI3K_p85beta	7..80	CDD:212842	1/1 (100%)
		RhoGAP	110..321	CDD:413382	45/255 (18%)
		SH2_nSH2_p85_like	337..445	CDD:198195	13/107 (12%)
		iSH2_PIK3R2	450..610	CDD:214019	18/169 (11%)
		SH2_cSH2_p85_like	628..730	CDD:198184	30/123 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910