DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Srms

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001011961.1	Gene:	Srms / 296472	RGDID:	1306602	Length:	507	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	149/487 - (30%)
Similarity:	232/487 - (47%)	Gaps:	62/487 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   881 PAGQKPVKPSVQISGHKDHPFESSSGELDENS-------------DRDIDNDEEEEDSASDDVLS 932
            |||:.. :...:|.|..|:|.......::..|             |......||...|..|.:.:
  Rat    32 PAGESE-EDIPRIQGQDDNPVPEQPAAVEPCSFPAPRARLFRALYDFTARCAEELSVSRGDRLYA 95

  Fly   933 MKDHCYCV--------PSL----AASISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFL 981
            :|:....:        ||.    ...::.:|.....::.|:...:.|.:..:||    |..|.||
  Rat    96 LKEEGEYIFAQRLSGPPSTGLVPVTYLAKATPETPSDQPWYFNGISRTQAQQLLLSPANAPGAFL 160

  Fly   982 VRETIRNEESQI---------VLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSE- 1036
            :|.:    ||.|         ...||   |....:..:| |.:..||..|.|:..|:.: |.:.
  Rat   161 IRPS----ESSIGGYSLSVRAQAKVC---HYRICMAPSG-GLYLQEGRLFPSLDALLAY-YKTNW 216

  Fly  1037 --LPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAK-LKSTKLDV-AVKTCRMT 1097
              :...:....:.:.|:.::.||....:.||..::|.|.||:|::.. |.||.:.| .:|:..|.
  Rat   217 KLIQNPLLQPCVPQMPLAQDEWERPRSEFVLRRKLGEGFFGEVWEGLWLGSTPVAVKVIKSADMK 281

  Fly  1098 LPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYL-RKNSNGLTTRQ 1161
            |.|..|     |...||...|..:::|..||...:|:.||.||:..|:|..|| ......|:...
  Rat   282 LADLTK-----EIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSPEGKALSLPH 341

  Fly  1162 QMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPV 1224
            .:|.....|.||.|||.:..:||||||||.||..:.:.|::|||::|  :::.|..|.|.| |||
  Rat   342 LLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSK-IPV 405

  Fly  1225 KWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEM 1289
            |||||||.|:..::...||||:|||::|:|:.|..||.||||....::|..|||:|.|...|.|:
  Rat   406 KWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEGMTNHETLQQISRGYRLPRPAVCPAEV 470

  Fly  1290 YRLMLQCWAADAESRPHFDEIYNVVDALILRL 1321
            |.||::||....|.||.|..:...::|:..||
  Rat   471 YMLMVECWKGSPEERPTFATLREKLNAINRRL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/101 (23%)
		TyrKc	1063..1311	CDD:197581	103/252 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/252 (40%)
Srms	NP_001011961.1	SH3	70..124	CDD:302595	8/53 (15%)
		SH2	134..212	CDD:301589	22/86 (26%)
		PTKc_Srm_Brk	238..498	CDD:133248	105/265 (40%)
		Pkinase_Tyr	245..495	CDD:285015	103/255 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910