DRSC - DRSC Integrative Ortholog Prediction Tool

DRSC/TRiP Functional Genomics Resources

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Protein Alignment FER and Tesk1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_113766.1	Gene:	Tesk1 / 29460	RGDID:	62059	Length:	628	Species:	Rattus norvegicus

Alignment Length:		Identity:	/ - (0%)
Similarity:	/ - (0%)	Gaps:	/ - (0%)

- Green bases have known domain annotations that are detailed below.

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
Tesk1	NP_113766.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		TyrKc	56..306	CDD:197581
		PKc_TESK	58..313	CDD:271057
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..376
		Required for interaction with YWHAB. /evidence=ECO:0000269\|PubMed:11555644	421..526
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..490
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000269\|PubMed:17974561	529..628
		Required for interaction with PARVA. /evidence=ECO:0000269\|PubMed:15817463	529..626
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910

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