Protein Alignment FER and ABL2

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_009298.1
• Gene: ABL2 / 27
• HGNCID: 77
• Length: 1182
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 137/386 - (35%)
• Similarity: 211/386 - (54%)
• Gaps: 34/386 - (8%)

  Fly   955 LYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFR 1016
            |.:..|:||.:.|.....||::  :|.|||||: .:...|:.:|:.:.|. .|:.:.||.:|...
Human   168 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRES-ESSPGQLSISLRYEGRVYHYRINTTADGKVY 231

  Fly  1017 FEGPP-FASIQELIMHQYHSELPVTVKSGAILR----RPVC-----------RERWELSNDDVVL 1065
            ..... |:::.||:.|  ||    ||..|.:..    .|.|           .::||:...|:.:
Human   232 VTAESRFSTLAELVHH--HS----TVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITM 290

  Fly  1066 LERIGRGNFGDVYKAKLKSTKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICV 1129
            ..::|.|.:|:||....|...|.|||||.:. |:..|:   ||:|..::|:..|||:|:|:|:|.
Human   291 KHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEE---FLKEAAVMKEIKHPNLVQLLGVCT 352

  Fly  1130 QKQPIMIVMELVLGGSLLTYLRK-NSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLV 1193
            .:.|..||.|.:..|:||.|||: |...:|....:.|....::.|.|||.||.||||||||||||
Human   353 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV 417

  Fly  1194 DLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSK 1256
            ...|.||::|||:||  ..:.|....|.| .|:||||||:|.:..::...|||::|:|:|||.:.
Human   418 GENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATY 481

  Fly  1257 GDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDAL 1317
            |.:||.|:..|:..:.::.||||..|:..|.::|.||..||......||.|.|.:...:.:
Human   482 GMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETM 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	26/87 (30%)
		TyrKc	1063..1311	CDD:197581	103/251 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/251 (41%)
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784
		SH2_ABL	169..262	CDD:198189	28/99 (28%)
		PTKc_Abl	281..543	CDD:270645	106/266 (40%)
		Pkinase_Tyr	288..539	CDD:285015	103/254 (41%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810