DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and C34F11.5

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_494971.1	Gene:	C34F11.5 / 266855	WormBaseID:	WBGene00016416	Length:	894	Species:	Caenorhabditis elegans

Alignment Length:	449	Identity:	111/449 - (24%)
Similarity:	198/449 - (44%)	Gaps:	76/449 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   900 PFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGV 964
            |.|:|.|    :|.|...||.:::       :..|:.               .|..:.::||.|:
Worm    50 PLETSYG----SSKRRRPNDWKKK-------MRKKER---------------KRRYFRQDWFWGM 88

  Fly   965 LPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNF-RFEGPPFASIQ 1026
            :.:.|....|.:  .|:||||..:..:...:|:.|        :|.:.....| :|:..|..|..
Worm    89 ITQTEAEGHLKDCRHGEFLVRSMLFQDNPIVVIDV--------VVVSDKSRTFQQFQASPVVSKW 145

  Fly  1027 ELIMH-QYHSELPVTV---------KSGAILRRPVCRERWELSNDDVVLLE---RIGRGNFGDV- 1077
            :|..: ..|..|...|         .:|..|:....:..|.|.:.:::..:   .:|.|.:|.|
Worm   146 QLDSYPSRHKTLVDLVAYYNRHFIGMTGLKLKTAAKQPDWFLKSYNIMCPKNAVNLGSGQYGCVA 210

  Fly  1078 ---YKAKLKSTKLDVAVKTCRMTLPDEQ----KRKFLQEGRILKQYDHPNIVKLIGICVQKQPIM 1135
               |:.:|      ||:|  ::|...|:    :...|:|...:::..||.|.|:|||.:.|.|.|
Worm   211 IGAYRRRL------VAIK--KLTSSGERLLLDREALLKEAMFMQKLQHPYITKIIGISIDKTPPM 267

  Fly  1136 IVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVK 1200
            :::|| :...||.:|:|.....|..:::......|.|:.::..:|.:|||:||||.|......||
Worm   268 LLIEL-MACPLLDHLQKYGKYTTIGEKLLYLWQLARGLSFMAKENVVHRDIAARNVLFSRHGIVK 331

  Fly  1201 ISDFGMSREEEE-YIVSDGMKQIPVKWTAPEALN---FGKYTSLCDVWSYGILMWEIFSKGDTPY 1261
            :||.|:|..|.: ..|:...:::|..|..||:::   ..|:....|||.:|....|:|..|..||
Worm   332 VSDLGLSDYESKLQAVNTSKERLPRAWLPPESVSKTGGNKFNEKTDVWMFGATSVEVFQNGQPPY 396

  Fly  1262 SGMTNSRARERI----DTGYRMPTPKSTPEEMYRL-MLQCWAADAESRPHFDEIYNVVD 1315
            ..:....|..|:    |....:..||....|::.. ..:.:....|.|.:|:||.:|:|
Worm   397 HELKWKEALPRLQNFKDGDNLLVFPKYASSEIHAFYSTKVFKRVNEDRVNFEEITSVLD 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	21/89 (24%)
		TyrKc	1063..1311	CDD:197581	73/267 (27%)
		PTKc_Fes_like	1067..1315	CDD:270637	75/267 (28%)
C34F11.5	NP_494971.1	SH2	82..170	CDD:214585	21/95 (22%)
		PTKc	201..455	CDD:270623	75/262 (29%)
		TyrKc	201..454	CDD:197581	74/261 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900