DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and T21G5.1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001355382.1	Gene:	T21G5.1 / 266839	WormBaseID:	WBGene00020659	Length:	514	Species:	Caenorhabditis elegans

Alignment Length:	360	Identity:	128/360 - (35%)
Similarity:	213/360 - (59%)	Gaps:	16/360 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   959 EWFHGVLPREEVVRLLNNDGDFLVR--ETIRNEESQ-IVLSVCWN-GHKHFIVQTTGEGNFRFEG 1019
            :::||::||.:....|...||:|:|  |...|...| :::||... |..|..:....||..:|..
Worm    78 QFYHGIIPRVDAELSLRYVGDYLLRRAEPRENAGGQFLIISVKREAGFVHVPISQDKEGAKQFYF 142

  Fly  1020 PPFA---SIQELI-MHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKA 1080
            .|..   ::.:|| :|...:: ||.|:....||:||.|..|.:.::||:|..:||.|.||:|:.|
Worm   143 MPTLKENTVLDLIDVHLARAQ-PVCVQWNVYLRKPVLRATWIIPHEDVILYRKIGSGAFGEVFLA 206

  Fly  1081 KL----KSTKLDVAVKTCRMTLPDEQKRKFLQEGR-ILKQYDHPNIVKLIGICVQKQPIMIVMEL 1140
            ::    ....||.|||..:.....:.|.:|::|.| :||.|.|.:||.:.||.....|::|:|||
Worm   207 RMVDPTSEYVLDCAVKKLKQEATMDAKLRFMKEARMMLKNYKHKHIVMIFGIATLNSPLLILMEL 271

  Fly  1141 VLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFG 1205
            ...|||::|||||...:|..:::....:|::|:.|||...|||||:||||||:..::.:||||.|
Worm   272 CPNGSLISYLRKNKGKVTLLEKLRFSAEASSGLAYLEKMECIHRDIAARNCLLSAKNEIKISDLG 336

  Fly  1206 MSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRAR 1270
            :: :::..::...:.::|:||.|||.:....|:...|:|::||::||||::||.||.|:.|::||
Worm   337 LA-DDKGMVIDYSLDKLPIKWLAPEIMQDKVYSLKSDIWAFGIMIWEIFAEGDEPYPGLNNTQAR 400

  Fly  1271 ERIDT-GYRMPTPKSTPEEMYRLMLQCWAADAESR 1304
            .:|.. .|||..|...|.|:.:::..||..|.:.|
Worm   401 AKIVVLDYRMKFPDEAPTELVQVIDTCWKKDPDMR 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/87 (26%)
		TyrKc	1063..1311	CDD:197581	95/248 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	93/244 (38%)
T21G5.1	NP_001355382.1	SH2_Fps_family	72..165	CDD:198224	23/87 (26%)
T21G5.1	NP_001355382.1	Pkinase_Tyr	189..438	CDD:336778	95/248 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74300
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm14377
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.820