DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and ZC581.7

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_491913.1	Gene:	ZC581.7 / 266838	WormBaseID:	WBGene00022634	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	393	Identity:	120/393 - (30%)
Similarity:	200/393 - (50%)	Gaps:	29/393 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   949 LSTNRPLYEEE----WFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQT 1009
            ::....:.||:    ::||.|..::..:||.||||:::...:..|.:::.|         ::...
Worm     1 MANKEKILEEDINLPYYHGALMNQDADQLLVNDGDYMIVVKMNQELNKMQL---------YLAVR 56

  Fly  1010 TGEGNFRFE-----------GPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDV 1063
            ..:|..|||           |....:|.:|:.......:.:..:. .||:|.:.:.:::|.:.||
Worm    57 LKKGIRRFEIKRNPTSAKIGGKSAPNIGKLVDSMQKETMEIKGER-VILKRAIPKGKFQLMHKDV 120

  Fly  1064 VLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQK-RKFLQEGRILKQYDHPNIVKLIGI 1127
            ...:::|.|.:|.||..:|......:|||.......||:. .:.::|.|:::.||||||||..|.
Worm   121 DFKKKLGSGAYGTVYLGRLTKNNTKIAVKKLDTEGNDEESLAEMMKEARVMQLYDHPNIVKFYGY 185

  Fly  1128 CVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCL 1192
            .|...|.::|:||..|||:...|.:....|:|:.::.....||.|:.||..|.|||||:||||||
Worm   186 IVDDIPYLLVLELCNGGSVEDKLVEKGAKLSTKTRIMYTYHAACGIEYLHKKKCIHRDIAARNCL 250

  Fly  1193 VDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFS-K 1256
            :..| .|||:||||.|....|.| |..|....:|.|||..:.|:.....|::::.|.|||.|. .
Worm   251 IHKE-IVKIADFGMCRATSIYKV-DLNKPTNTRWLAPEVWDNGETRDNTDIFAFAITMWEFFEVP 313

  Fly  1257 GDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRL 1321
            .|:|||.......:::...|||:||||..|.::..:|..||..|...||...|:...::..:.:.
Worm   314 YDSPYSEWKGYMVKQKTRAGYRLPTPKGMPWDIEEIMKLCWHVDPNQRPTASELREKIEETMAKP 378

  Fly  1322 DNS 1324
            ::|
Worm   379 ESS 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	20/100 (20%)
		TyrKc	1063..1311	CDD:197581	94/249 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	93/249 (37%)
ZC581.7	NP_491913.1	SH2	9..97	CDD:301589	20/96 (21%)
		Pkinase_Tyr	120..371	CDD:285015	94/252 (37%)
		PTKc	124..372	CDD:270623	93/249 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810