DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and csk-1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001293162.1	Gene:	csk-1 / 266817	WormBaseID:	WBGene00000812	Length:	624	Species:	Caenorhabditis elegans

Alignment Length:	651	Identity:	171/651 - (26%)
Similarity:	281/651 - (43%)	Gaps:	97/651 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   716 FSKSPLVRMGKNHILNEEQDAKRTQPS--QHHHSSGSDCPTNSSSSSSNN-----NNNNKNTSSN 773
            ||.|    ..::|..|.....|.:..|  :..||.|....:.:||.|||:     .|.||.....
Worm     4 FSAS----RSRSHHRNSRNPTKFSNFSIEKRSHSLGGSSSSPTSSFSSNDEFDDRQNKNKFWRQR 64

  Fly   774 SNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSK 838
            :..:|....||...|...|...:.......:.:....:| |...|.:|::..|...||.......
Worm    65 NVSNAEIERIIEDFIANGILKMSNGNSYNHHHQFPMSIP-ISCSSHSIQSQSRMNTLNANRDLLS 128

  Fly   839 PCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPS--VQISGHKDHP- 900
            |.......|.:.||                      .:.:..||.....:..  |:|.|:...|
Worm   129 PGNDVIVTRTVSPS----------------------FYSHGMPARDNVFRKDDHVRILGNTTDPA 171

  Fly   901 -FESSSGELDE---NSDRDIDNDEEEEDSASDDVLSMK-DHCYCVPSLAASISLSTNR---PLYE 957
             :.:.:...:|   ::|..:..:.:..|:.   ::.|: ..|...|..|::.|.:::.   ....
Worm   172 WYRARNANQEEGLVHADCVVRINGQAYDNG---IVRMRASGCDVAPGAASTTSSTSSHHSTAANH 233

  Fly   958 EEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFRFEG 1019
            :.|||.::.||...:||..  ||.|||||: .|......|.:.::|. :|:.::.|..|....:.
Worm   234 QPWFHSMISRENTEKLLRGKPDGTFLVRES-TNFPGDFTLCMSFHGKVEHYRIEQTSGGQLTCDK 297

  Fly  1020 PP-FASIQELIMHQ--------YHSELPVTVKSGAIL-----------------RRPVCRER-WE 1057
            .. |:::.:|:.|.        :....|:..::....                 |..|.|.. ..
Worm   298 EEYFSNLTQLVSHYKRDADGLCHRLVTPIICETATFSSNGSSSFGSSSTVDLEDRTSVFRHAGLV 362

  Fly  1058 LSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKR-------KFLQEGRILKQ 1115
            :|::|:.:.:.||.|.||||.....|:.|  ||:|.        .||       ..|.|.:.:..
Worm   363 ISSNDIDVGDTIGHGEFGDVRLGTYKNRK--VALKV--------SKRHGNGMLDSLLDEAKFMVG 417

  Fly  1116 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR-KNSNGLTTRQQMGMCRDAAAGMRYLESK 1179
            ..|||:|.|:|:.:....:.::.|.:..|:|:..|| :..:.|..||.|....|...||.|||||
Worm   418 LSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGRHALERRQLMMFAMDICQGMCYLESK 482

  Fly  1180 NCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVW 1244
            ..:||||||||.|:|.:...|:||||::::...........:.|:||||||||...::|:..|||
Worm   483 QIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVW 547

  Fly  1245 SYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDE 1309
            |:|||:|||||.|..||..:........|:.||||..|:..|.|::::|.:.||..|:.||.|.:
Worm   548 SFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQ 612

  Fly  1310 I 1310
            :
Worm   613 V 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/100 (23%)
		TyrKc	1063..1311	CDD:197581	94/256 (37%)
		PTKc_Fes_like	1067..1315	CDD:270637	94/252 (37%)
csk-1	NP_001293162.1	SH2_csk_like	232..330	CDD:198190	24/98 (24%)
		PTKc_Csk_like	362..620	CDD:270635	96/262 (37%)
		STYKc	368..617	CDD:214568	94/256 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910