DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Hck

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_037317.2	Gene:	Hck / 25734	RGDID:	2785	Length:	524	Species:	Rattus norvegicus

Alignment Length:	420	Identity:	152/420 - (36%)
Similarity:	227/420 - (54%)	Gaps:	62/420 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   931 LSMKDHCYCVPS--LAASISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRE----- 984
            |:.|...| :||  :|...||.|      ||||...:.|::..|.|    |..|.|::|:
  Rat   118 LATKKEGY-IPSNYVARVNSLET------EEWFFKGISRKDAERHLLAPGNMLGSFMIRDSETTK 175

  Fly   985 -----TIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGP--PFASIQELIMH---------QY 1033
                 ::|:.:.|...:|     ||:.::|...|.| :..|  .|:|:|||::|         |.
  Rat   176 GSYSLSVRDFDPQHGDTV-----KHYKIRTLDSGGF-YISPRSTFSSLQELVVHYKKGKDGLCQK 234

  Fly  1034 HSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKL-KSTKLDVAVKTCRMT 1097
            .|...|:.|.    ::|..::.||:..:.:.:.:::|.|.||:|:.|.. |.||  |||||.:
  Rat   235 LSVPCVSPKP----QKPWEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTK--VAVKTMK-- 291

  Fly  1098 LPDEQK-RKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQ 1161
             |.... ..||.|..::|...|..:|||..: |.::||.||.|.:..||||.:| |:..|  ::|
  Rat   292 -PGSMSVEAFLAEANLMKTLQHDKLVKLHAV-VSQEPIFIVTEFMAKGSLLDFL-KSEEG--SKQ 351

  Fly  1162 QMGMCRDAAA----GMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMK 1220
            .:....|.:|    ||.::|.:|.|||||.|.|.||......||:|||::|  |:.||...:|.|
  Rat   352 PLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAK 416

  Fly  1221 QIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKST 1285
             .|:|||||||:|||.:|...||||:|||:.||.:.|..||.||:|......::.|||||.|.:.
  Rat   417 -FPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDNC 480

  Fly  1286 PEEMYRLMLQCWAADAESRPHFDEIYNVVD 1315
            |||:|.:|::||....|.||.|:.|.:|:|
  Rat   481 PEELYSIMIRCWKNRPEERPTFEYIQSVLD 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	28/110 (25%)
		TyrKc	1063..1311	CDD:197581	107/255 (42%)
		PTKc_Fes_like	1067..1315	CDD:270637	109/255 (43%)
Hck	NP_037317.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..71
		SH3	80..135	CDD:302595	6/17 (35%)
		SH2_Src_HCK	138..241	CDD:198226	29/114 (25%)
		PKc_like	252..522	CDD:304357	112/269 (42%)
		Pkinase_Tyr	260..509	CDD:285015	108/258 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910