DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Pik3r1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_037137.2	Gene:	Pik3r1 / 25513	RGDID:	3329	Length:	724	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	145/759 - (19%)
Similarity:	239/759 - (31%)	Gaps:	251/759 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   418 NGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQ 482
            ||||  :........||              |.:...||......||:|..|            :
  Rat    57 NGYN--ETTGERGDFPG--------------TYVEYIGRKRISPPTPKPRPP------------R 93

  Fly   483 PRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRL------RR 541
            |...:.||.....|...|               ..::..|.|:.|.....||.|.:|      :.
  Rat    94 PLPVAPGSSKTEADTEQP---------------VLTLPDLAEQFAPPDVAPPLLIKLLEAIEKKG 143

  Fly   542 TQCSMLCLGEDEEPVVLASPAPLTQL----TAAVLTNTNNNHIYADL------------------ 584
            .:||.|...:..     ::||.|.||    .|:|..:..:.|:.||.
  Rat   144 LECSTLYRTQSS-----SNPAELRQLLDCDAASVDLDVFDVHVLADAFKRYLADLPNPVIPVAVY 203

  Fly   585 -ELDKKKDTSPSPECKGEQIQPKKEQIR-------------------IEINQTAPQNSIDAHLDR 629
             |:.......||.|   :.||..|:.||                   .:::|.:.:|.::|.
  Rat   204 NEMMSLAQEVPSSE---DYIQLLKKLIRSPNIPHQYWLTLQYLLKHFFKLSQASSKNLLNAR--- 262

  Fly   630 IDELNRVLDDRLKRTLQPSDD-----VNAIE---SAEENHIQ-TRKLAKDPDSQTKRSSSSSSEC 685
              .|:.:....|.|....|.|     :.|:|   |.|.:..| ...|...|...|..:::|.:..
  Rat   263 --ALSEIFSHVLFRFPAASSDNTEHLIKAVELLISTEWSERQPAPALPPKPPKPTSIANNSMNNN 325

  Fly   686 RS-----------SKDTSHSKKRSLS--------FSQKSISNIFSNLKEFSKSPLVRM----GK- 726
            .|           |::..:.|.|..:        .|.|...:....|::...:.|:::    ||
  Rat   326 MSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKY 390

  Fly   727 ---------------NHILNE-------EQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKN 769
                           ||..||       :.|.|...|...:.........|..:.....:..|..
  Rat   391 GFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQ 455

  Fly   770 TSSNSNH---------SASQSTIITSTITTTITTT---------TTTTPSKENSRLKFKVPKIQK 816
            ....|..         ..||...:..|.......|         |....|||... |||....:|
  Rat   456 FQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIE-KFKREGNEK 519

  Fly   817 KSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEF-EVEQPAGSAADEQFCNCP 880
            :.:.|.:       |....:|:..:....|||:  .:.:...|.|: |:::...|
  Rat   520 EIQRIMH-------NHDKLKSRISEIIDSRRRL--EEDLKKQAAEYREIDKRMNS---------- 565

  Fly   881 PAGQKPVKPS-VQISGHKDHPF---------ESSSGEL--DENSDRDIDNDEEEEDSASDDVLSM 933
                  :||. :|:...:|...         :....|.  :||::......|::||....|
  Rat   566 ------IKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHD---- 620

  Fly   934 KDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLL--NNDGDFLVRETIRNEESQIVLS 996
                                   |:.|..|...|.:...||  ..||.|||||:  :::.....|
  Rat   621 -----------------------EKTWNVGSSNRNKAENLLRGKRDGTFLVRES--SKQGCYACS 660

  Fly   997 VCWNGH-KHFIVQTTGEGNFRFEGP--PFASIQELIMHQYHSEL 1037
            |..:|. ||.::..|..| :.|..|  .::|::||::|..|:.|
  Rat   661 VVVDGEVKHCVINKTATG-YGFAEPYNLYSSLKELVLHYQHTSL 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	28/90 (31%)
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
Pik3r1	NP_037137.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..109		8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910