DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and ppk1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_593534.2	Gene:	ppk1 / 2541715	PomBaseID:	SPAC110.01	Length:	1023	Species:	Schizosaccharomyces pombe

Alignment Length:	1019	Identity:	209/1019 - (20%)
Similarity:	341/1019 - (33%)	Gaps:	343/1019 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 DLTLEQNFIENGYNNEQQRSNST------SSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQP 466
            |:...|:.|.|.|.......:||      ||     ::.|.|     :..:....|......|||
pombe    12 DVQSFQDIISNSYQKPLSLVDSTDRALPDSS-----LSSLSR-----STFQFHKHHLSGNENPQP 66

  Fly   467 A------TPMTRSRQGRF-----NKLQP----RSQSLGSLSVIRDGNGPSPARYEP--------- 507
            :      |...|.....|     |:|.|    ..|::.|.|..|...||    |.|
pombe    67 SSESPYFTNNERLNSSSFPQIHDNQLSPSFNTSYQAIPSSSSNRSRGGP----YTPSIRDDSLLA 127

  Fly   508 ----ITNHRLRQAASVHYLGEEI-----ATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAP 563
                .:||||      |.:..::     |:|.|.|                           .||
pombe   128 LLSFSSNHRL------HSMPSQLQPFNNASSYTTP---------------------------MAP 159

  Fly   564 LTQLTAAVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLD 628
            .|    |..:|..::..|....|       ||...|...|:      |:.:|
pombe   160 FT----ASFSNKVSHSAYPTRRL-------PSQAKKTSAIE------RVPVN------------- 194

  Fly   629 RIDELNRVLDDRLKRTLQPSDDVN--------AIESAEENHIQTRKLAKDPDSQTKRSSSSSSEC 685
                ||.:..|.|  .:|.|...|        .|.|.|:  ::||::...| .||.:.|:.:.:.
pombe   195 ----LNFLQSDNL--VVQSSPQTNFENFEFPKKIPSKED--LETREVLLLP-PQTSKLSNKNLDT 250

  Fly   686 RSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGS 750
            :|                      |:::.:.|:...|.:..|       .:|.|..:..|.|.|
pombe   251 KS----------------------FTDVNKISQQGFVEISSN-------SSKVTPNTSLHQSFG- 285

  Fly   751 DCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQ 815
                    .:|:::||...|||.                     .|::|.....|.      .:|
pombe   286 --------IASSSSNNYMQTSSE---------------------LTSSTEKMNGSH------PLQ 315

  Fly   816 KKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCP 880
            ..:|:        ||:..|.:||        .:.|.|.:..|         ...|....:..|.|
pombe   316 LSNKS--------LLSIHLMQSK--------NQGHVSMTGSD---------KLSSHVQSETENAP 355

  Fly   881 PAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAA 945
            .:  ||.||:......|  |.:|:  :|..||                  |::.: .|..|....
pombe   356 VS--KPSKPNTLTEDEK--PLQST--KLPGNS------------------LTVGE-LYQEPKSIQ 395

  Fly   946 SISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTT 1010
            ...||.:|..|..:                       ..:::|...:|..:......||.:.:..
pombe   396 LPELSVSRTTYSAQ-----------------------SSSVKNCNERIPSAKALKKQKHLVPENK 437

  Fly  1011 GEGNF---RFEGPPFASIQELI-MHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGR 1071
            .:..:   :.|..|:|::.... .|.:.||........  |.|.:.:.....:....:|...||.
pombe   438 SKLQYVWQKKESLPYANLTSASNTHFFLSENQNDTSER--LTRTLRKSTKNYTFGSYILGRTIGT 500

  Fly  1072 GNFGDVYKAKL------------KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQY--DHPNIV 1122
            |.||   |.||            :||. .|.:|....|..:.|..:.::|..|||..  :||:||
pombe   501 GEFG---KVKLGWPLPKANSTIHRSTP-QVVIKIVLSTKQNCQTSRLMREVAILKGLGNNHPHIV 561

  Fly  1123 KLIGICVQKQPIMIVMELVLGGSLLTYL---RKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHR 1184
            |.:.....|....||::.|.||.|..|:   |:..:.:..|    :.....:|:.||.|:..:||
pombe   562 KYLDFVKTKHHFGIVLDYVNGGELFDYILARRRLEDSVACR----LFAQLISGVAYLHSRGVVHR 622

  Fly  1185 DLAARNCLVDLEHSVKISDFGMSREEEEY-IVSDGMKQIPVK-------------WTAPEALN-- 1233
            ||...|.|:|...::.|:|||.:.....: .:|:  ..:|.:             :.|||.:|
pombe   623 DLKLENILLDTNRNIVIADFGFATTFGHFNTLSE--HSLPTEKPDLFSTSCGSPCYAAPELVNCK 685

  Fly  1234 FGKYT-SLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYR--MPTP-------KS---- 1284
            .|.|. :..|:||.|::::.:.: |..|:....::...|.:...||  ..||       ||
pombe   686 SGMYAGTQADIWSCGVILYAMLA-GYLPFDDDPHNPNGENVPRLYRYICSTPLIFPEFFKSKARD 749

  Fly  1285 ------TPEEMYRLMLQCWAADAESRPHFD--EIYNVVDALILR 1320
                  .|:...|:.:......|..|.|..  |.||..:|..||
pombe   750 ILKKILVPDPAKRVRMSAIMNHAYLRSHVSLFETYNDDEATSLR 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	12/89 (13%)
		TyrKc	1063..1311	CDD:197581	76/302 (25%)
		PTKc_Fes_like	1067..1315	CDD:270637	77/302 (25%)
ppk1	NP_593534.2	STKc_Kin4	490..774	CDD:270978	73/294 (25%)
ppk1	NP_593534.2	S_TKc	492..774	CDD:214567	73/292 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000